557763-60-7

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 14371-10-9 (E)-3-phenylpropenal 
• 101711-55-1 2‐((tert‐butyldimethylsilyl)oxy)ethan‐1‐amine 

Downstream Products

• 557763-39-0 (3RS,4SR,E)-1-(2-{[(N-tert-butoxycarbonyl-D-valyl)-L-leucyl-(N-ε-tert-butoxycarbonyl)-L-lysyl]amino}ethyl)-3-methoxy-4-(2-phenylethenyl)azetidin-2-one 

Relevant academic research and scientific papers

Cu-promoted single-pot intramolecular esterification of C-3 functionalized azetidin-2-one: An efficient diastereoselective access to azido-/amino-aza- lactones

A facile, single pot diastereoselective access to seven and eight membered aza-heterocycles was developed by using β-lactam-synthon approach. The developed protocol does not involve the typical intricacies viz. the use of expensive transition metal catalysts and high boiling solvents, associated with the convenient protocols.

Synthesis of intramolecularly activated lactenediynes and evaluation of their activity against plasmid DNA

The synthesis of new "selectively activated" enediyne prodrugs is reported. These compounds, belonging to the "lactenediyne" family, each possess a protected primary amine tethered at the β-lactam nitrogen. This, once deblocked, can act as a trigger, provoking a cascade of events probably terminating with Bergman cycloaromatization of the enediyne moiety. In vitro experiments on plasmid DNA have shown that the protected compounds are inactive, while the unprotected amine is able to provoke single-strand scissions. These results open the way towards development of enzymatically activated lactenediyne prodrugs. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.