55779-32-3 Usage
Description
AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE is a compound derived from the amino acid serine, which has been modified to include a hydroxamate group. This modification enhances its ability to interact with certain enzymes and cellular processes, making it a versatile molecule with potential applications in various fields.
Uses
Used in Biochemical Research:
AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE is used as an inhibitor of seryl-tRNA synthetase for studying the role of this enzyme in protein synthesis and its potential as a target for therapeutic intervention.
Used in Metabolic Synthesis Induction:
In the field of microbiology, AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE is used to induce metabolic synthesis of guanosine 3′-diphosphate 5′-diphosphate (ppGpp) in E. coli by amino acid starvation. This induction helps researchers understand the cellular response to nutrient limitation and the role of ppGpp in regulating gene expression.
Used in Cell Cycle Synchronization:
AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE is also used to synchronize the cell cycle in E. coli cultures by inhibiting tRNA charging. This application is valuable for studying the cell cycle and its regulation, as well as for developing new strategies to control bacterial growth and division.
Biochem/physiol Actions
Serine is involved in the one-carbon unit metabolism. It is associated with the biosynthesis of cysteine, ceramide, phosphatidylserine, purine and pyrimidine. In bacteria, it participates in tryptophan synthesis. Gluconeogenesis, one of the important biochemical processes, involves serine, particularly in ruminants. Protein phosphorylation is one such event that utilizes serine. Glycine, a metabolic product of serine, serves as an antioxidant and a neurotransmitter. D-serine is known to activate the N-methyl-D-aspartate (NMDA) receptors of the brain. Serine hydroxamate, a structural analogue of serine prevents seryl-tRNA (transfer ribonucleic acid) charging and thereby decreases phospholipid and nucleic acid synthesis in Escherichia coli.
Check Digit Verification of cas no
The CAS Registry Mumber 55779-32-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,7,7 and 9 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 55779-32:
(7*5)+(6*5)+(5*7)+(4*7)+(3*9)+(2*3)+(1*2)=163
163 % 10 = 3
So 55779-32-3 is a valid CAS Registry Number.
55779-32-3Relevant articles and documents
Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands
Cordi,Lacoste,Audinot,Millan
, p. 1409 - 1414 (2007/10/03)
The in vitro activities of 3-hydroxy-imidazolidin-4-one derivatives demonstrated very restricted structure-activity relationships at the strychnine-insensitive glycine site of the NMDA receptor. The most active compound (3a) was completely unsubstituted and exhibited affinity and efficacy similar to that of D-cycloserine, the prototypical partial agonist at this site.
