55784-52-6

Upstream product

• 461-89-2 6-azauracil 
• 17933-03-8 m-tolylboronic acid 

Downstream Products

• 38560-93-9 4-[4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-2-methyl-benzenesulfonyl]-morpholine 
• 74875-35-7 N-Allyl-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-2,N-dimethyl-benzenesulfonamide 
• 74875-37-9 4-(3,5-Dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-N-ethyl-N-isopropyl-2-methyl-benzenesulfonamide 
• 74875-36-8 N-Cyclopentyl-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-2,N-dimethyl-benzenesulfonamide 
• 74875-38-0 4-[4-(3,5-Dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-2-methyl-benzenesulfonyl]-piperazine-1-carbaldehyde 
• 74875-34-6 4-(3,5-Dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-2-methyl-benzenesulfonyl chloride 

Relevant academic research and scientific papers

A mild and efficient copper-mediated N-arylation of 6-azauracil with corresponding boronic acids and their antibacterial activity

A convenient synthetic strategy is reported for the synthesis of N-arylated 6-azauracil through Chan-Lam cross-coupling. A variety of N-arylated 6-azauracil derivatives were synthesized in moderate to good yields by cross-coupling of 6-azauracil with arylboronic acids in the presence of Cu(OAc)2 and pyridine. However the arylation position is confirmed in the case of 2-(3,5-dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione (3a), by preparing the compound in a traditional method and compared the chemical shift of the NH proton at N-3 position. Further, the synthesized compounds were screened for their antibacterial activity using agar well diffusion method. The results revealed that most of the synthesized moieties possessing promising therapeutic nature.