55788-97-1Relevant academic research and scientific papers
Synthesis and in vitro inhibitory activity on human platelet aggregation of novel properly substituted 4-(1-piperazinyl)coumarins
Di Braccio, Mario,Grossi, Giancarlo,Roma, Giorgio,Signorello, Maria Grazia,Leoncini, Giuliana
, p. 397 - 409 (2007/10/03)
Pursuing our chemical and biological studies in this field, we described the multistep preparation of the new 5-, 6-, or 7-alkoxy and 7-alkoxy-8-methyl substituted 4-(1-piperazinyl)coumarins 5d-v, as well as the in vitro evaluation of their inhibitory activity on human platelet aggregation induced in platelet-rich plasma by ADP, collagen or the Ca2+ ionophore A23187. Compounds 5h-j,p,r-u showed notably high activity towards all the platelet aggregation inducers used, and the most active one, 8-methyl-4-(1-piperazinyl)- 7-(3-pyridylmethoxy)coumarin (5t), proved to be a potent in vitro antiplatelet agent.
Partial Alkylation of 5,6-Dihydroxycoumarin : Synthesis of 6-Hydroxy-5-methoxy- and 5-Hydroxy-6-methoxy-coumarins
Ahluwalia, V. K.,Khanna, Manjula,Rani, Nimmi
, p. 343 - 344 (2007/10/02)
Partial methylation of 5,6-dihydroxycoumarin (II) gives 6-hydroxy-5-methoxycoumarin (III).The isomeric 5-hydroxy-6-methoxycoumarin (I) is obtained by partial benzylation of II followed by methylation and final catalytic debenzylation.The melting points of
