5579-49-7Relevant academic research and scientific papers
Butobarbitone metabolism in man: identification of 3' ketobutobarbitone
Grove,Toseland,Draffan,Clare,Williams
, p. 175 - 178 (1974)
After single 200 mg oral doses of butobarbitone (I) in man, 5.4% was excreted in urine unchanged and 28.2% as the 3' hydroxy metabolite (II) in 6 days. A new metabolite, the ketone (III), was detected in urine following oral administration both of I and of II. Oxidation of the hydroxy to the ketone metabolite was demonstrated in vitro with the 9000g fraction of rat liver. Use was made of selective ion monitoring gas chromatography mass spectrometry methods in metabolite detection.
