55790-20-0

Upstream product

• 81637-89-0 N-[acetylamino(4-bromophenyl)methyl]-acetamide 
• 110814-41-0 [(4-Bromo-phenyl)-(diethoxy-thiophosphorylamino)-methyl]-phosphonic acid diphenyl ester 
• 157635-97-7 N-(4-bromobenzylidene)-1,1-diphenylmethanimine 
• 122-52-1 triethyl phosphite 
• 55790-21-1 diethyl (α-amino-4-bromobenzyl)phosphonate hydrochloride 
• 1122-91-4 4-bromo-benzaldehyde 

Relevant academic research and scientific papers

Substituted phosphonic analogues of phenylglycine as inhibitors of phenylalanine ammonia lyase from potatoes

A series of phosphonic acid analogues of phenylglycine variously substituted in phenyl ring have been synthesized and evaluated for their inhibitory activity towards potato L-phenylalanine ammonia lyase. Most of the compounds appeared to act as moderate (

Sigmatropic isomerizations in azaallyl systems: XX. N- Alkylbenzimidoylphosphonates

Synthetic approaches are developed to benzimidoylphosphoryl derivatives containing electronically and sterically diverse alkyl substituents on the nitrogen atom, as well as their prototropic isomers. Regularities in prototropic transitions in the phosphorylated C=N-C triad were revealed and applied in the synthesis of α-aminophosphonic acid derivatives. 2004 MAIK "Nauka/Interperiodica".

Inhibitors of phenylalanine ammonialyase: 1-aminobenzylphosphonic acids substituted in the benzene ring

Dextrorotatory 1-amino-3′,4′-dichlorobenzylphosphonic acid was found to be a potent inhibitor of the plant enzyme phenylalanine ammonia-lyase both in vitro and in vivo from among the ring-substituted 1-aminobenzylphosphonic acids and other analogues of phenylglycine. A structure activity relationship analysis of the results obtained permits predictions on the geometry of the pocket of the enzyme and is a basis in the strategy of better inhibitor synthesis.

The synthesis of 1-aminobenzylphosphonic acids from benzylidenediphenylmethylamines, for use as structural units in antithrombotic tripeptides

Acid hydrolyses of O,O-dimethyl or O,O-diethyl 1-(diphenylmethylamino) benzylphosphonate intermediates 2, formed from the addition at elevated temperature of dimethyl or diethyl phosphite to benzylidenediphenylmethylamines 1, generates 1-aminobenzylphosphonic acids 3 in good yield.

Synthesis of 1-Aminoalkylphosphonic Acids via Amidoalkylation of Phosphorous Acid by N,N'-Alkylidenbisamides

N,N'-Alkylidenebisamides 1, totally unsuitable as amidoalkylating agents toward phosphorous acid, react with its "activated" form prepared "in situ" from phosphorous(III) chloride and acetic acid to give the desired 1-amidoalkylphosphonic acids 2 in high yield.

Studies on Organophosphorus Compounds XXVIII. An Improved Synthetic Route to 1-Amino-Substituted Benzyl Phosphonic and -Phosphinic Acids

An improved method for the synthesis of 1-aminosubstituted benzyl phosphonic and -phosphinic acids under mild conditions is described.It consists of the reaction of diphenoxy chlorophosphine (1) or dichlorophenylphosphine (6) with substituted benzaldehyde