55810-82-7Relevant academic research and scientific papers
Concise synthesis of highly substituted benzo[a]quinolizines by a multicomponent reaction/allylation/heck reaction sequence
Den Heeten, Rene,Van Der Boon, Leon J. P.,Broere, Daniel L. J.,Janssen, Elwin,De Kanter, Frans J. J.,Ruijter, Eelco,Orru, Romano V. A.
supporting information; experimental part, p. 275 - 280 (2012/02/04)
The combination of the recently developed multicomponent construction of highly substituted 3,4-dihydropyridones with subsequent allylation and intramolecular Heck-type cyclization allows the straightforward construction of benzo[a]quinolizines, a class of polycyclic compounds that- despite their interesting pharmacological and photochemical properties- have little precedent in the literature. After optimization of the individual steps, we used this reliable three-step sequence to generate a small library of diversely substituted benzo[a]quinolizines and various heterocyclic analogs. Copyright
