55817-78-2

Usage

Chemical category

Indole derivatives
Indole derivatives are compounds that have a core structure of indole, which is a bicyclic aromatic system consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring.

Heterocyclic compound

Carbon and nitrogen atoms
Heterocyclic compounds are those that contain at least one atom other than carbon in their ring structure. In this case, the compound has a ring structure made up of carbon and nitrogen atoms.

Nitrile group

–C≡N
The nitrile group is a functional group consisting of a carbon-nitrogen triple bond (C≡N). The presence of this group in the molecule indicates its potential use in organic synthesis and medicinal chemistry.

Amino group

–NH2
The amino group is a functional group consisting of a nitrogen atom bonded to two hydrogen atoms (–NH2). The presence of this group in the compound suggests its potential for biological activity and pharmaceutical applications.

Phenyl group

C6H5
The phenyl group is a functional group consisting of a six-membered benzene ring (C6H5). The presence of this group in the compound also suggests its potential for biological activity and pharmaceutical applications.

Tetrahydro

Four hydrogen atoms in the ring structure

Potential uses

Synthesis of pharmaceutical drugs and building block for new compounds
Due to the presence of various functional groups and its heterocyclic nature, this chemical may have diverse uses, including in the synthesis of pharmaceutical drugs and as a building block for the creation of new compounds with potential pharmacological activity.

Upstream product

• 62-53-3 aniline 
• 533-60-8 cyclohexanone-2-ol 
• 109-77-3 malononitrile 
• 88-05-1 2,4,6-trimethylaniline 

Downstream Products

• 130147-75-0 9-Phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indole-2,4-dithiol 
• 56344-59-3 9-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indol-4-ylamine 
• 152421-47-1 5,6,7,8-tetrahydro-2,9-diphenyl-9H-pyrimido<4,5-b>indole-4-amine 
• 144658-61-7 2-<(3-Cyano-1-phenyl-4,5,6,7-tetrahydro-1H-indol-2-yl)amino>-2-butendisaeuredimethylester 
• 77651-39-9 2-amino-4,5-tetramethylene-1-phenyl-3-pyrrolecarboxamide 

Relevant academic research and scientific papers

Synthesis of 8,9,10,11-tetrahydroindolo[2,1-c]benzo[1,2,4]triazine. A new ring system

Indolo[2,1-c]benzo[1,2,4]triazine, a new ring system, was synthesized by diazotization of 2-amino-1 aryltetrahydroindoles followed by an intramolecular coupling of the diazonium group with the aryl moiety. All the new compounds were screened at the NCI fo

Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives

Disclosed are compounds of the formula: wherein Ar, R1, W, X and m are substituents as defined herein. These compounds are modulators of CRF receptors and are therefore useful for treating affective disorder, anxiety, depression, headache, irri

Substituted 9H-pyridino [2,3-B]indole and 9H-pyrimidino [4,5-B]indole derivatives: selective neuropeptide Y receptor ligands

Disclosed are compounds of the formula: wherein Ar, R1, W and X are substituents as defined herein, which compounds are effective neuropeptide Y1 receptor antagonists, and are therefore useful in the treatment of a wide variety of clinical cond

Aminoalkyl substituted 5,6,7,8-tetrahydro-9H-pyridino [2, 3-B] indole and 5,6,7,8-tetrahydro-9H-pyrimidino [4, 5-B] indole derivatives: CRF1 specific ligands

Disclosed are compounds of the formula: wherein Ar, R1, W, X and m are substituents as defined herein. These compounds are modulators of CRF receptors and are therefore useful for treating affective disorder, anxiety, depression, headache, irri

9H-pyrimido [4,5-b] indole derivatives: CRF1 specific ligands

Disclosed are compounds of the formula: wherein Ar, R1, R2, R3, R4and R5are defined herein, which compounds are selective antagonists at CRF1 receptors and are therefore useful in the diagnosis and tr

Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives

Disclosed are compounds of the formula: wherein Ar, R1, W and X are substituents as defined herein, which compounds are (1) antagonists at CRF1 receptors and are, therefore, useful in the diagnosis and treatment of stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety; and (2) are neuropeptide Y1 receptor antagonists, and are therefore useful in the treatment of a variety of clinical conditions which are characterized by the presence of an excess of neuropeptide Y.

Synthesis of Substituted Indoles and Pyrimidoindoles by Dehydrogebation of Tetrahydroindoles and Tetrahydropyrimidoindoles

The synthesis of N1-substituted 2-amino-4,5,6,7-tetrahydroindole-3-carbonitriles 2 and 5,6,7,8-tetrahydropyrimidoindoles 3-5 and their subsequent dehydrogenation to the corresponding 2-aminoindole-3-carbonitriles 8 and pyrimidoind