55822-19-0Relevant academic research and scientific papers
Synthesis of cytotoxic cembranolide analogues via acid-induced opening of oxiranes
Rodríguez, Abimael D.,Pi?a, Ivette C.,Acosta, Ana L.,Barnes, Charles L.
, p. 93 - 107 (2001)
A large series of analogues of Eunicea cembranolides 1-3 were synthesized with the purpose of evaluating their cytotoxicity against 60 human cancer cell-lines. Most of the analogues were as active as the lead compounds and a few displayed increased cytotoxicity. Their syntheses were based on the specific reactivity and stereochemistry of the epoxide substructure and involved highly regio- and diastereoselective acid-induced chemical transformations.
