55823-68-2Relevant academic research and scientific papers
REDUCED COENZYME Q10 DERIVATIVE AND METHOD FOR PRODUCTION THEREOF
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Paragraph 0130-0132, (2015/11/16)
A reduced coenzyme Q10 derivative represented by formula (1), wherein R1 and R2 are each independently H or an alkoxycarbonyl group represented by formula (2), and at least one of them is an alkoxycarbonyl group represente
Active oxygen chemistry within the liposomal bilayer: Part III: Locating Vitamin E, ubiquinol and ubiquinone and their derivatives in the lipid bilayer
Afri, Michal,Ehrenberg, Benjamin,Talmon, Yeshayahu,Schmidt, Judith,Cohen, Yael,Frimer, Aryeh A.
, p. 107 - 121 (2007/10/03)
We have previously shown that the location and orientation of compounds intercalated within the lipid bilayer can be qualitatively determined using an NMR chemical shift-polarity correlation. We describe herein the results of our application of this method to analogs of Vitamin E, ubiquinol and ubiquinone. The results indicate that tocopherol - and presumably the corresponding tocopheroxyl radical - reside adjacent to the interface, and can, therefore, abstract a hydrogen atom from ascorbic acid. On the other hand, the decaprenyl substituted ubiquinol and ubiquinone lie substantially deeper within the lipid membrane. Yet, contrary to the prevailing literature, their location is far from being the same. Ubiquinone-10 is situated above the long-chain fatty acid slab . Ubiquinol-10 dwells well within the lipid slab, presumably out of striking range of Vitamin C. Nevertheless, ubiquinol can act as an antioxidant by reducing C- or O-centered lipid radicals or by recycling the lipid-resident tocopheroxyl radical.
