55824-91-4Relevant academic research and scientific papers
2-ARYL-7-SUBSTITUTED PYRAZOLO[1,5a]1,3,5-TRIAZINES
-
, (2014/02/13)
2-aryl-7-substituted pyrazolo[1,5a]1,3,5-triazine derivatives are disclosed which are useful as 3',5'-cyclic AMP phosphodiesterase inhibitors. These compounds are prepared by condensation of aryl- beta -ketonitrile derivatives with thiosemicarbazide which affords the corresponding 3-amino-2-thiocarbamoyl-5-aryl pyrazoles which, when heated with diethoxymethylacetate, give 2-aryl-7-mercapto pyrazolo [1,5a]1,3,5-triazines. The mercapto derivatives may then be methylated with methyl iodide to afford 2-aryl-7-methylthio-pyrazolo[1,5a]1,3,5,-triazines. Nucleophilic displacement of the methylthio moiety with various amines and sodium alkoxides yields the appropriately substituted 2-aryl-7-substituted pyrazolo[1,5a]1,3,5-triazines
