55828-12-1

Upstream product

• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 121-33-5 vanillin 
• 10543-12-1 4-acetoxy-3-methoxybenzoic acid 

Downstream Products

• 99499-12-4 4-hydroxy-N-isobutyl-3-methoxybenzamide 
• 146978-52-1 4-hydroxy-3-methoxy-N,N-bis(1-methylethyl)benzenecarboxamide 
• 1067189-51-8 N-[4-(1-cyano-cyclopentyl)-phenyl]-4-hydroxy-3-methoxy-benzamide 
• 1393588-64-1 2-methoxy-4-(5-methyloxazol-2-yl)phenol 
• 100377-63-7 4-hydroxy-3-methoxybenzoic hydrazide 
• 109257-46-7 4-hydroxy-3-methoxy-benzoic acid anilide 
• 1067189-58-5 N-[4-(1-cyano-cyclopentyl)-phenyl]-4-isopropoxy-3-methoxy-benzamide 
• 1346498-79-0 (4-hydroxy-3-methoxyphenyl)(spiro[benzo[b]pyrrolo[1,2-d][1,4]oxazine-4,4'-piperidine]-1'-yl)methanone 

Relevant academic research and scientific papers

Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi

Trypanosoma cruzi is the causing agent of Chagas disease, a parasitic infection without efficient treatment for chronic patients. Despite the efforts, no new drugs have been approved for this disease in the last 60 years. Molecular modifications based on

Design, Synthesis and Molecular Docking of Vanillic Acid Derivatives as Amylolytic Enzyme Inhibitors

In the present work, a series of vanillic acid derivatives have been synthesized and tested to exhibit promising amylolytic enzymes inhibition. Structures of the synthesized derivatives were studied by FT-IR, 1H NMR, 13C NMR, EI-MS,

Synthesis and antioxidant activity of 1,3,4-oxadiazoles and their diacylhydrazine precursors derived from phenolic acids

Eight 1,3,4-oxadiazole derivatives containing phenolic acid moieties (7a-h) and eight of their diacylhydrazine precursors (6a-h) were synthesized, characterized using spectroscopic methods and examined by scavenging of stable DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals. The most potent phenolic 1,3,4-oxadiazoles showed better DPPH scavenging activity in comparison with their corresponding diacylhydrazine precursors as a result of participation of both aromatic rings and a 1,3,4-oxadiazole moiety in resonance stabilization of the formed phenoxyl radical. Four diacylhydrazines (6d, 6e, 6g, and 6h) and four 1,3,4-oxadiazoles (7d, 7e, 7g and 7h) with the best DPPH scavenging activity, were chosen for further evaluation of their antioxidant potential through various assays. The investigated compounds exerted pronounced ABTS radical scavenging capacity, moderate to good H2O2 scavenging properties and strong ferric ion reducing capacity. Further in vitro evaluation of the antioxidant properties of the most active compounds demonstrated their protective effects in normal lung fibroblasts MRC-5 against hydrogen peroxide induced oxidative stress. Diacylhydrazine 6h increased two times the activity of glutathione peroxidase in treated cells in comparison with a control sample and did not affect the superoxide dismutase activity.

Synthesis of inulin esters of phenylcarboxylic acids

Inulin esters were synthesized containing residues of ferulic, p-hydroxycinnamic, and vanillic acids with a maximum degree of substitution of 1.1. The inulin acylation was carried out with chlorides of 4-acetoxy derivatives of the corresponding hydroxyphenylcarboxylic acids in a heterogenic water-organic environment. The removal of the protecting acetyl group at the phenol hydroxyl was carried out by treating with pyrrolidine or ammonium acetate. The solubility of the esters obtained was evaluated.

Diaryl-1,2,4-oxadiazole antioxidants: Synthesis and properties of inhibiting the oxidation of DNA and scavenging radicals

Six 1,2,4-oxadiazole derivatives were prepared in order to compare their abilities to protect DNA against radical-mediated oxidation and to scavenge radicals. These derivatives had a structure based on disubstituted 1,2,4-oxadiazole, in which a vanillin group (A ring) and a substituted benzene group (B ring) were the substituents. The functional group at B ring was assigned as ortho- or meta-hydroxylbenzene group, ortho-chlorobenzene group, no group contained, and pyridine group or vanillin group at B ring. It was found that the compound with two vanillin groups attaching to oxadiazole can trap 2.05 radicals in protecting DNA against 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH)-induced oxidation, and the compound with an ortho-hydroxylbenzene group at B ring can trap 1.78 radicals. The compound with an ortho-chlorobenzene group at B ring exhibited the highest ability to inhibit ·OH-induced oxidation of DNA, while the compound with a meta-hydroxylbenzene group at B ring inhibited Cu2+/glutathione (GSH)-induced oxidation of DNA efficiently. The ortho- and para-hydroxylbenzene groups at B ring made the compounds possess the highest rate constant (k) in scavenging 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate) cationic radical (ABTS+.) and 2,2′-diphenyl-1-picrylhydrazyl radical (DPPH). Therefore, only a few hydroxyl groups can markedly enhance the activity of the core-branched antioxidant, which may be a novel structural feature in designing antioxidant.

HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS

The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the comp

NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE

The present invention provides new compounds of formula I, wherein Q, R1, R2, R4, R5, R6, Xi, R7, R8, M and G1 nare defined as in formula I; invention compounds are modulators of follicle-stimulating hormone - ("FSH") which are useful for male and female contraception as well as other disorders modulated by FSH receptor.

NO-mediated aromatic nitration during decomposition of phenolic S-nitrosothiols in non-aqueous aerobic medium

Five novel S-nitrosothiol compounds (6-10) derived from L-cysteine were generated in solution and their decomposition rate was followed by UV spectroscopy. In acetonitrile, compounds 9 and 10 were the most stable of this series with a half-life of 24 h. T

Indole derivative for treating overproduction of dihydrotestosterone

The present invention relates to an indole derivative represented by formula (1) or a salt thereof, and a pharmaceutical containing the derivative or the salt: STR1 wherein R 1 represents lower alkyl; R 2 represents hydrogen or phenyl which may be substit

3-Amino-1,2-benzisoxazoles: A new family of potent inhibitors of LTB4 binding to the human neutrophils

A new family of 3-amino-1,2-benzisoxazoles was designed and synthesized to be a potent inhibitors of LTB4 binding to the human neutrophils HS-1141 appears to be one of the strongest inhibitors of LTB4 binding reported so far (IC