55830-46-1Relevant academic research and scientific papers
1,8-NAPHTHALIMIDE IMIDAZO{4,5,1-DE}ACRIDONES WITH ANTI-TUMOR ACTIVITY
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, (2008/06/13)
The invention provides imidazoacridone compounds of general formula (1) which have cytotoxic and anti-tumor activity. The invention also provides methods of preparing the compounds, and methods of using the compounds for the treatment of cancer or other m
2-(Aminoalkyl)-5-nitropyrazoloacridines, a New Class of Anticancer Agents
Capps, David B.,Dunbar, James,Kesten, Suzanne R.,Shillis, Joan,Werbel, Leslie M.,et al.
, p. 4770 - 4778 (2007/10/02)
2-(Aminoalkyl)-5-nitropyrazoloacridines were prepared from substituted anilines via the 1-chloro-4-nitroacridones followed by condensation with hydrazines.Impressive activity was demonstrated for the 9-hydroxy, 9-alkoxy, and 9-acyloxy analogs in vitro on a L1210 leukemia line and in vivo against the P388 leukemia.Advanced studies led to the selection of 3bbb for clinical trial.
Pyrazolo[3,4,5-kl]acridine compositions and methods for their production and use
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, (2008/06/13)
Pyrazolo[3,4,5-kl]acridines are described as antibacterial agents and antitumor agents as well as pharmaceutical compositions and methods for their preparation.
Use of 2,6-Dichlorobenzonitrile (Dichlobenil) as Starting Material for Synthesis of Herbicides, Derivatives of Benzoic Acid.
Romanowski,Wituch-Zapalowska,Eckstein
, p. 26 - 31,27, 28, 30 (2007/10/06)
Results of an investigation are presented in which S//N reactions of dichlobenil and its transformation products were investigated using as nucleophilic agents for chlorine exchange: sodium methanolate and ethanolate, as well as aniline and its derivatives. It has been shown that the ability to enter the reaction of mono- or disubstitution is dependent on the kind of derivative of 2,6-dichloro-3-nitrobenzoic acid, as well as on conditions of reactions. In the manner described above, dichlobenil has been transformed into valuable herbicide, dicamba, i. e. 3,6-dichloro-2-methoxybenzoic acid. A mixture of isomeric acids has been obtained, their herbicide activity having the same range.
