55835-19-3

Upstream product

• 94534-87-9 (8R,9S,10R,13S,14S)-6-bromo-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[α]phenanthrene-3,17(6H)-dione 
• 897-06-3 Androsta-1,4-diene-3,17-dione 
• 27759-21-3 6β-bromo-androsta-1,4-diene-3,17-dione 

Downstream Products

• 1338324-85-8 (8R,9S,10R,13S,14S)-4-(benzyloxy)-3-hydroxy-10,13-dimethyl-9,10,11,12,13,14,15,16-octahydro-7H-cyclopenta[α]phenanthren-17(8H)-one 
• 1380397-41-0 (8R,9S,10R,13S,14S)-10,13-dimethyl-3,17-dioxo-4,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[α]phenanthren-4-yl 2-phenylacetate 
• 1338324-48-3 (8R,9S,10R,13S,14S)-4-(benzyloxy)-3-hydroxy-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[α]phenanthren-17(2H)-one 
• 1338324-53-0 (6R,8R,9S,10R,13S,14S)-10,13-dimethyl-3,17-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[α]phenanthren-6-yl 2-phenylacetate 

Relevant academic research and scientific papers

Convenient method for the functionalization of the 4- and 6-positions of the androgen skeleton

The preparation and reactivity of steroidal vinyldiazo compounds is reported, providing a convenient, substituent tolerant, chemo- and stereoselective entry into 4- and 6-substituted androgen analogues from a common precursor. Under dirhodium catalysis, O-H insertion occurs at the carbenoid site, leading to 4-substituted steroids, but under silver catalysis, O-H insertion occurs at the vinylogous position, leading to 6-substituted steroids.

SUBSTITUTED ANDROST-4-ENE DIONES

The disclosure relates to novel C4 and C6 substituted androst-4-ene diones as well as andros-1,4-diene diones and derivatives thereof, their process of preparation, pharmaceutical compounds containing them, and the use of said compounds for the treatment of hormone-related disorders in mammals. This includes hormone-dependent cancers, particularly those caused by elevated levels of estrogen and its intermediates. These compounds can also be used in the treatment of other hormone-related disorders, inluding benign prostatic hyperplasia, cardiovascular disease, and neurodegenerative disorders.

Androst-4-en-19-ols

Derivatives of androst-4-en-19-ol are useful for enhancing libido and related psychic attitudes.

Androst-4-en-19-ones for the enhancement of libido

The present invention concerns androst-4-en-19-ones which are useful in the enhancement of libido and related pyschic attitudes.

19-Oxygenated-5α-androstanes for the enhancement of libido

Derivatives of 19-oxygenated-5α-androstanes are described which are useful in enhancing the libido and related psychic attitudes in mammals.

Androst-4-en-19-ols for the enhancement of libido

Derivatives of androst-4-en-19-ol are described which are useful in enhancing the libido and related psychic attitudes in primates.

Androst-4-en-19-ones

The present invention concerns derivatives of androst-4-en-19-one which are useful in the enhancement of libido and related psychic attitudes.