558441-71-7Relevant articles and documents
Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors
Hack, Silke,W?rlein, Babette,H?fner, Georg,Pabel, J?rg,Wanner, Klaus T.
experimental part, p. 1483 - 1498 (2011/05/11)
A new series of potential GABA uptake inhibitors starting from of 1H-imidazol-4-ylacetic acid with the carboxylic acid side chain originating from different positions and varying in length have been synthesized and tested for the inhibitory potency at the
Chemokine receptor binding heterocyclic compounds with enhanced efficacy
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, (2008/06/13)
The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).