558472-49-4Relevant academic research and scientific papers
Synthesis of 2,6-disubstituted piperidine-bearing α-amino acid side-chains
Boeglin, Damien,Heitz, Annie,Martinez, Jean,Fehrentz, Jean-Alain
, p. 3139 - 3146 (2007/10/03)
A straightforward synthesis of 2,6-disubstituted piperidines bearing α-amino acid side-chains was developed. Synthesis was based on a Horner-Wadsworth-Emmons condensation of a β-ketophosphonate derived from an α-amino acid residue with a β-homologated ald
One-pot hydrogenation conditions for a sequential process to (+)-monomorine
Kim, Guncheol,Jung, Sung-do,Lee, Eun-ju,Kim, Nakjeong
, p. 5395 - 5398 (2007/10/03)
(+)-Monomorine has been synthesized under mild hydrogenation conditions initiating deprotection followed by intramolecular, sequential reductive amination reactions. The precursors could be prepared concisely using B-alkyl Suzuki cross coupling of a chiral homoallylamine and a vinyl iodide or an iodofuran derivative.
Peptide based inhibitors of interleukin-8: Structural simplification and enhanced potency
Attwood, Michael R.,Conway, Elizabeth A.,Dunsdon, Rachel M.,Greening, John R.,Handa, Balraj K.,Jones, Philip S.,Jordan, Steven C.,Keech, Elizabeth,Wilson, Francis X.
, p. 429 - 432 (2007/10/03)
Important areas of a lead peptide inhibitor of IL-8 had been previously identified. Chemical modification led to the identification of key amide bonds which allowed the replacement of the central section of the peptide with modified amino acids and spacers. This approach led to inhibitors of lower molecular weight and of increased potency.
