55849-04-2Relevant academic research and scientific papers
Synthesis with perfect atom economy: Generation of diazo ketones by 1,3-dipolar cycloaddition of nitrous oxide at cyclic alkynes under mild conditions
Banert, Klaus,Plefka, Oliver
supporting information; scheme or table, p. 6171 - 6174 (2011/09/13)
A cascade of five steps, transforms cyclooctynes in the presence of nucleophiles NuH and nitrous oxide, into the depicted products (see scheme). In another example, nitrous oxide was added at a cycloalkyne at -25 °C to generate the corresponding diazo ket
