55851-38-2

Basic information

• Product Name: N,N-Dimethyl-2-Nitro-5-Aminoaniline
• Synonyms: N,N-Dimethyl-2-Nitro-5-Aminoaniline
• CAS NO: 55851-38-2
• Molecular Weight: 181.194
• Mol File: 55851-38-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N,N-Dimethyl-2-Nitro-5-Aminoaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Dimethyl-2-Nitro-5-Aminoaniline(55851-38-2)
• EPA Substance Registry System: N,N-Dimethyl-2-Nitro-5-Aminoaniline(55851-38-2)

Safety Data

• Hazardous Substances Data: 55851-38-2(Hazardous Substances Data)

Upstream product

• 88914-67-4 3'-(dimethylamino)-4'-nitroacetanilide 
• 712-33-4 3-chloro-4-nitroacetanilide 

Downstream Products

• 88413-20-1 3'-(dimethylamino)-4'-nitromethanesulfonanilide 
• 108835-51-4 [4-(Acridin-9-ylamino)-3-dimethylamino-phenyl]-phosphoramidic acid dimethyl ester 
• 88914-59-4 [4-(Acridin-9-ylamino)-3-dimethylamino-phenyl]-carbamic acid methyl ester 
• 108835-93-4 dimethyl N-<3-(dimethylamino)-4-nitrophenyl>phosphoramidate 
• 108835-98-9 (4-Amino-3-dimethylamino-phenyl)-phosphoramidic acid dimethyl ester 
• 88915-02-0 (4-Amino-3-dimethylamino-phenyl)-carbamic acid methyl ester 
• 88914-69-6 4'-amino-3'-(dimethylamino)methanesulfonanilide 
• 106542-98-7 9-(2-Dimethylamino-4-methanesulfonylamino-phenylamino)-acridine-4-carboxylic acid carbamoylmethyl-amide; hydrochloride 
• 106521-44-2 9-(2-Dimethylamino-4-methanesulfonylamino-phenylamino)-5-methoxy-acridine-4-carboxylic acid methylamide; hydrochloride 
• 88913-83-1 6-Chloro-9-(2-dimethylamino-4-methanesulfonylamino-phenylamino)-acridine-4-carboxylic acid methylamide; hydrochloride 
• 88913-87-5 9-(2-Dimethylamino-4-methanesulfonylamino-phenylamino)-5-methyl-acridine-4-carboxylic acid methylamide; hydrochloride 
• 106521-42-0 N-[4-(3-Chloro-5-methoxy-acridin-9-ylamino)-3-dimethylamino-phenyl]-methanesulfonamide; hydrochloride 
• 88913-79-5 9-(2-Dimethylamino-4-methanesulfonylamino-phenylamino)-acridine-4-carboxylic acid methylamide; hydrochloride 
• 88913-86-4 N-[4-(4,5-Dimethoxy-acridin-9-ylamino)-3-dimethylamino-phenyl]-methanesulfonamide; hydrochloride 

Relevant articles and documents

Potential Antitumor Agents. 48. 3'-Dimethylamino Derivatives of Amsacrine: Redox Chemistry and in Vivo Tumor Activity

Structure-activity relationships for a series of acridine-substituted 3'-N(CH3)2 derivatives of the clinical antileukemic drug amsacrine (1) are reported.The parent (unsubstituted) compound 3 has activity against the Lewis lung solid tumor that is superior to amsacrine(1), the new clinical amsacrine analogue 4, and the recently developed 3'-NHCH3 derivative 2.Although the compounds generally bind less well to DNA and are less dose potent in vivo than either their amsacrine (3'-OCH3) or 3'-NHCH3 analogues, they show very high levels of antitumor activity, with the 4-OCH3 derivative capable of effecting 100percent cures of the Lewis lung solid tumor.The broad structure-activity relationships for acridine substitution more closely resemble those of the amsacrine than the 3'-NHCH3 series, with 4-substituted and 4,5-disubstituted compounds showing the highest activity.

Substituted o-phenylenediamine acridine compounds having antitumor activity

Compounds represented by the general formula (I): STR1 in which R1 represents STR2 A and B each represent H or a lower alkane optionally substituted with amino and/or hydroxyl functions, except that A and B are not both H; R3 represe