55862-00-5

Usage

Structure

1H-1,2,3-Triazole, 4-(3-methylphenyl)-

Explanation

The structure consists of a 1,2,3-triazole ring, which is a five-membered heterocyclic compound with three nitrogen atoms and a single hydrogen atom attached to each nitrogen atom. The 4-(3-methylphenyl)substitution indicates a 3-methylphenyl group attached to the 4-position of the triazole ring.
3. Heterocyclic compound

Explanation

A heterocyclic compound is a cyclic compound containing atoms of at least two different elements, in this case, carbon, hydrogen, and nitrogen.
4. Presence of 3-methylphenyl group

Explanation

The 3-methylphenyl group is an aromatic ring with a methyl group attached to the third carbon atom. This substitution occurs at the 4-position of the triazole ring.

Explanation

The compound has a wide range of applications due to its diverse biological activities, making it useful in various industries.

Explanation

The compound exhibits various biological activities, which contribute to its use in different fields. These activities include fighting fungal infections, bacterial infections, and potentially inhibiting the growth of cancer cells.
7. Derivative of 1,2,3-triazole

Explanation

The compound is derived from the parent compound 1,2,3-triazole, which is a five-membered heterocyclic compound containing three nitrogen atoms. The 4-(3-methylphenyl)substitution differentiates it from the parent compound.

Applications

Pharmaceuticals, agrochemicals, and materials science

Biological activities

Antifungal, antibacterial, and antitumor properties

Upstream product

• 29835-27-6 3-(3-methylphenyl)prop-2-ynoic acid 
• 22568-43-0 1-methyl-3-(2-nitrovinyl)benzene 
• 620-23-5 m-tolyl aldehyde 
• 585-74-0 3-Methylacetophenone 
• 75-52-5 nitromethane 
• 766-82-5 1-ethynyl-3-methyl-benzene 

Downstream Products

• 1594930-01-4 C₂₄H₂₀N₄ 
• 1594929-14-2 1-benzyl-2-(4-(m-tolyl)-2H-1,2,3-triazol-2-yl)-1H-indole 

Relevant academic research and scientific papers

Direct Synthesis of 4-Aryl-1,2,3-triazoles via I2-Promoted Cyclization under Metal- And Azide-Free Conditions

We herein report an iodine-mediated formal [2 + 2 + 1] cyclization of methyl ketones, p-toluenesulfonyl hydrazines, and 1-aminopyridinium iodide for preparation of 4-aryl-NH-1,2,3-triazoles under metal- and azide-free conditions. Notably, this is achieved

Method of catalytically synthesizing 4-aryl-NH-1,2,3-triazole derivative under microwave radiation

The invention discloses a method of catalytically synthesizing 4-aryl-NH-1,2,3-triazole derivative under microwave radiation. The method includes the steps of: successively adding substituted 2-nitroolefin, sodium azide, TfOH, and pyridine into a reaction

On Water Cu@g-C3N4 Catalyzed Synthesis of NH-1,2,3-Triazoles via [2+3] Cycloadditions of Nitroolefins/Alkynes and Sodium Azide

Here, we have reported fabrication of graphitic polymeric C3N4 supported CuCl2 (Cu@g-C3N4) and characterized by powder X-ray diffraction, field emission scanning electron microscopy, high resolution transmission electron microscopy, X-ray photoelectron spectroscopy studies. An efficient and regioselective protocol for the on water synthesis of 4-aryl-NH-1,2,3-triazole derivatives via 1,3-diipolar cycloaddition reactions of nitroolefins/phenylacetylenes to sodium azide were demonstrated by using Cu@g-C3N4 as robust and reusable catalyst.

One-Pot Synthesis of 4-Aryl-NH-1,2,3-Triazoles through Three-Component Reaction of Aldehydes, Nitroalkanes and NaN3

A one-pot three-component reaction of aldehydes, nitroalkanes and NaN3 for the synthesis of NH-1,2,3-triazoles has been developed. The reaction provides a safe, efficient and step-economic approach for the synthesis of various NH-1,2,3-triazoles in good to excellent yields.

4-Aryl- NH -1,2,3-Triazoles via Multicomponent Reaction of Aldehydes, Nitroalkanes, and Sodium Azide

4-Aryl-NH-1,2,3-triazoles are valuable compounds in organic chemistry and pharmaceutical chemistry. In this paper, we describe a novel multicomponent reaction of aldehydes, nitroalkanes, and sodium azide for the synthesis of 4-aryl-NH-1,2,3-triazoles. In this transformation, it was found that both the slow addition of nitroalkane and the presence of NaHSO3/Na2SO3 are advantageous to promote the reaction results. Additionally, a series of aldehydes and nitro compounds were investigated.

Preparation of reusable Ag-decorated graphene oxide catalysts for decarboxylative cycloaddition

In this study, we demonstrated a noble Ag-decorated graphene oxide catalyst (GOSH-Ag) for use in the decarboxylative cycloaddition reaction. The catalyst was easily prepared by depositing Ag nanoparticles on thiolated graphene oxide (GOSH) surfaces. Trans

Compounds and methods

Compounds of this invention are non-peptide, reversible inhibitors of type 2 methionine aminopeptidase, useful in treating conditions mediated by angiogenesis, such as cancer, haemangioma, proliferative retinophathy, rheumatoid arthritis, atherosclerotic