558640-51-0

Basic information

• Product Name: VER-49009
• Synonyms: 5-(5-Chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide;CCT 129397
• CAS NO: 558640-51-0
• Molecular Formula: C19H18ClN3O4
• Molecular Weight: 387.81692
• EINECS: 604-604-1
• Mol File: 558640-51-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: VER-49009(CAS DataBase Reference)
• NIST Chemistry Reference: VER-49009(558640-51-0)
• EPA Substance Registry System: VER-49009(558640-51-0)

Safety Data

• Hazardous Substances Data: 558640-51-0(Hazardous Substances Data)

Usage

Description

VER-49009, also known as a heat shock protein 90 (HSP90) inhibitor, is a pharmaceutical compound that plays a crucial role in modulating the cellular stress response and protein homeostasis. It is characterized by its ability to induce the expression of HSP72 and HSP27, while simultaneously depleting client proteins such as C-RAF, B-RAF, survivin, and the protein arginine methyltransferase PRMT5. This unique mechanism of action makes VER-49009 a promising candidate for various therapeutic applications.

Uses

Used in Pharmaceutical Industry:
VER-49009 is used as a therapeutic agent for targeting the heat shock protein 90 (HSP90) pathway, which is often dysregulated in various diseases, including cancer. By inhibiting HSP90, VER-49009 disrupts the stability and function of its client proteins, leading to their degradation and potentially offering therapeutic benefits in the treatment of cancer and other HSP90-associated diseases.
Used in Cancer Research:
In cancer research, VER-49009 is used as a tool to study the role of HSP90 in tumor growth, survival, and resistance to chemotherapy. Its ability to deplete client proteins such as C-RAF, B-RAF, and survivin makes it a valuable compound for investigating the molecular mechanisms underlying cancer progression and the development of drug resistance.
Used in Drug Development:
VER-49009 is utilized in drug development as a lead compound for the design and synthesis of novel HSP90 inhibitors. Its unique mechanism of action and potential therapeutic benefits make it an attractive starting point for the development of new drugs targeting the HSP90 pathway in various diseases, including cancer.
Used in Drug Delivery Systems:
To enhance the efficacy and bioavailability of VER-49009, researchers are exploring various drug delivery systems, such as nanoparticles and liposomes, to improve its pharmacokinetic properties and target its delivery to specific tissues or cells. These novel drug delivery systems aim to maximize the therapeutic potential of VER-49009 while minimizing potential side effects and toxicity.