558645-24-2Relevant academic research and scientific papers
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design
Dymock, Brian W.,Barril, Xavier,Brough, Paul A.,Cansfield, Julie E.,Massey, Andrew,McDonald, Edward,Hubbard, Roderick E.,Surgenor, Allan,Roughley, Stephen D.,Webb, Paul,Workman, Paul,Wright, Lisa,Drysdale, Martin J.
, p. 4212 - 4215 (2007/10/03)
The crystal structure of a previously reported screening hit 1 (CCT018159) bound to the N terminal domain of molecular chaperone Hsp90 has been used to design 5-amide analogues. These exhibit enhanced potency against the target in binding and functional a
PYRAZOLE COMPOUNDS AS HSP90 INHIBITORS FOR THE TREATMENT OF CANCER
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Page/Page column 15, (2008/06/13)
Compounds of formula (I) are inhibitors of HSP90 activity, and useful in the treatment of proliferative disease such as cancers: wherein R1, R2 and R3 are as defined in the specification, and X is -OR4 or - NR4R5 wherein R4 and R5 independently represent
