55875-29-1

Upstream product

• 105492-16-8 3-Phenylindole-2-carboxazide 
• 62-53-3 aniline 
• 55875-30-4 2-amino-3-phenylindole 

Relevant academic research and scientific papers

Synthesis of biheterocycles containing indole nucleus

Indole-2-carboxyhydrazides (2) when reacted with phenacylbromide or chloroacetone in dry ethanol and DMF yield 2-(6'-phenyl/methyl-1',2',4'-triazin-3'-yl)indoles (5 and 7).A suitable reaction mechanism for the formation of these compounds (5 and 7) has be

Fused isoquinoline derivatives

Fused isoquinoline derivatives of the general formula STR1 wherein: A is a divalent radical selected from the groups STR2 wherein R3 and R4 each independently represents hydrogen, alkyl,, alkenyl, cycloalkyl, aryl, aralkyl, aralkenyl, cycloalkyl-alkyl or, taken together with the adjacent double bond, represent a cycloalkene containing from 5 to 8 carbon atoms or an aromatic nucleus; R5 represents hydrogen, hydroxyl, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, aralkenyl or cycloalkyl-alkyl; Y is =O, =S or =NH; X is --O--, --S-- or --NR6 -- wherein R6 represents hydrogen, alkyl, cycloalkyl, aryl, aralkyl or cycloalkyl-alkyl; R1 and R2 each independently represents hydrogen, alkyl, phenyl, cycloalkyl, alkoxy, alkenyloxy, methylenedioxy, cycloalkoxy, halo or di-alkylamino or, taken together with the adjacent carbon atoms of the benzene ring, form a cycloalkenyl group containing 5 or 6 carbon atoms or an aromatic nucleus fused on the benzene ring. The compounds are essentially prepared through thermal cyclization of a compound of the formula STR3 wherein A, X, Y, R1 and R2 have the same meanings given before, with the proviso that R1 and R2 cannot simultaneously occupy both the ortho positions, B represents hydrogen, R represents an --OR7 or --NR8 R9 radical wherein R7 is alkyl, aryl or aralkyl and R8 and R9 each independently represents hydrogen, alkyl, aryl, aralkyl, or taken together with the adjacent nitrogen atom represent a heterocyclic saturated radical of 5 or 6 atoms which may contain a further hetero-atom selected from oxygen and nitrogen, or the symbols B and R taken together represent a further bond between the adjacent carbon and nitrogen atoms.

Antiinflammatory 2-imino-indolines and their pharmaceutical compositions

Compounds with antiinflammatory, analgesic and CNS depressant activity having the following general formula SPC1 Wherein R represents hydrogen or methoxy; R1 represents hydrogen; lower alkyl; lower alkyl substituted with a group carboxy, carbo(lower alkoxy) or carbamyl; phenyl; benzyl, lower aliphatic acyl; benzoyl; benzoyl substituted with a halo group; R2 represents hydrogen; lower alkyl; carbo(lower alkoxy); carbamyl; phenylcarbamyl; lower aliphatic acyl; benzoyl; benzoyl substituted with a halo group, R3 represents halo; lower alkyl; lower alkyl substituted with a group selected from carboxy, carbo(lower alkoxy), carbamyl, halo, amino, mono and di-lower alkylamino, phthalimido and morpholino; phenyl; phenyl substituted with a group selected from lower alkoxy, halo, nitro, amino and acetamido; R4 represents hydrogen or lower alkyl; with the proviso that when simultaneously R1 represents hydrogen, methyl, phenyl, benzyl, acetyl or benzoyl, R2 represents hydrogen, lower alkyl or acetyl, R3 represents lower alkyl or phenyl, R4 must be different from hydrogen and methyl; Or R3 and R4 taken together with the adjacent carbon atom may represent a 5-6 membered alicyclic ring.