55875-44-0Relevant academic research and scientific papers
A curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in Alzheimer's disease
Park, Kwang-Su,Seo, Yujin,Kim, Mi Kyoung,Kim, Kyungdo,Kim, Yun Kyung,Choo, Hyunah,Chong, Youhoon
supporting information, p. 11194 - 11199 (2015/11/27)
In recent years, there has been growing interest in the near-infrared (NIR) fluorescence imaging of tau fibrils for the early diagnosis of Alzheimer's disease (AD). In order to develop a curcumin-based NIR fluorescent probe for tau fibrils, structural modification of the curcumin scaffold was attempted by combining the following rationales: the curcumin derivative should preserve its binding affinity to tau fibrils, and, upon binding to tau fibrils, the probe should show favorable fluorescence properties. To meet these requirements, we designed a novel curcumin scaffold with various aromatic substituents. Among the series, the curcumin derivative 1c with a (4-dimethylamino-2,6-dimethoxy)phenyl moiety showed a significant change in its fluorescence properties (22.9-fold increase in quantum yield; Kd, 0.77 μM; λem, 620 nm; Φ, 0.32) after binding to tau fibrils. In addition, fluorescence imaging of tau-green fluorescent protein-transfected SHSY-5Y cells with 1c confirmed that 1c detected tau fibrils in live cells.
Benzylideneamino- and phenylacetylguanidines and their pharmaceutical uses
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, (2008/06/13)
Compounds of formula (I): STR1 or a salt or acyl derivative thereof; wherein Y is either --CH=N or STR2 R1 is hydroxy, halogen, (C1-4) alkyl, or (C1-4)alkoxy, R2 is a nitrogen-containing, basic substituent, R3 is hydrogen, hydroxy, halogen, (C1-4) alkyl, (C1-4) alkoxy or a nitrogen-containing, basic substituent, and R4 is hydrogen or hydroxy, are useful in treating diarrhoea and scours.
Amphetamine derivatives
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, (2008/06/13)
Compounds having the general formula STR1 or pharmaceutically acceptable salts thereof, in which formula R1 and R2 are the same or different and each represents a hydrogen atom, a lower alkyl group or a halogen atom, R3 represents a lower alkyl group or a benzyl group, R4 represents a hydrogen atom, a lower alkyl group, a benzyl group or a CH2 CH2 CH2 --bridge connected to the phenyl ring in ortho-position relative to the N-substituent, R5 represents a hydrogen atom or a methyl group and R6 represents a lower alkyl group, provided that R1 and/or R2 represents a lower alkyl group or a halogen atom when R3 represents a methyl group, R4 represents a methyl group and R5 represents a hydrogen atom; methods for the preparation thereof; intermediates useful for their preparation; pharmaceutical preparations containing at least one of these compounds; and the use thereof in the treatment of depressive states and alleviating anxiety.
