55878-47-2

Basic information

• Product Name: BOC-D-LYS(Z)-OH
• Synonyms: BOC-N-EPSILON-Z-D-LYSINE;BOC-D-LYSINE(CBZ);BOC-D-LYSINE(Z)-OH;N-ALPHA-BUTOXYCARBONYL-N-EPSILON-CARBOBENZOXY-D-LYSINE;N-ALPHA-BOC-N-EPSILON-BENZYLOXYCARBONYL-D-LYSINE;N-ALPHA-TERT-BUTYLOXYCARBONYL-N-EPSILON-BENZYLOXYCARBONYL-D-LYSINE;N2-[(1,1-Dimethylethoxy)Carbonyl]-N6-[(Phenylmethoxy)Carbonyl]-D-Lysine;Nalpha-Boc-Nepsilon-Z-D-lysine
• CAS NO: 55878-47-2
• Molecular Formula: C₁₉H₂₈N₂O₆
• Molecular Weight: 380.44
• Mol File: 55878-47-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 587°Cat760mmHg
• Flash Point: 308.8°C
• Appearance: /
• Density: 1.176g/cm³
• Storage Temp.: Store at RT.
• PKA: 3.99±0.21(Predicted)
• CAS DataBase Reference: BOC-D-LYS(Z)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-LYS(Z)-OH(55878-47-2)
• EPA Substance Registry System: BOC-D-LYS(Z)-OH(55878-47-2)

Safety Data

• Hazardous Substances Data: 55878-47-2(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 34404-32-5 (R)-2-amino-6-(((benzyloxy)carbonyl)amino)hexanoic acid 
• 106719-44-2 Boc-D-Lys-OH 
• 501-53-1 benzyl chloroformate 
• 923-27-3 D-lysine 
• 7274-88-6 D-lysine hydrochloride 
• 32302-83-3 N-ε-benzyloxycarbonyl lysine 

Downstream Products

• 96523-81-8 Boc-D-Lys(Z)-D-Ala-OBzl 
• 164224-88-8 (R)-1-((R)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoyl)-piperidine-3-carboxylic acid methyl ester 
• 164224-44-6 N^α-Boc-D-Lys(Cbz)-(S)-(+)-Nip-OMe 
• 218927-55-0 (S)-3-[3-((S)-2-Acetylamino-2-benzyloxycarbonyl-ethyl)-phenyl]-2-((S)-6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-propionic acid methyl ester 
• 864739-01-5 N²-(1,1-dimethylethoxycarbonyl)-N⁶-(phenylmethoxycarbonyl)-D-lysine-2-phenethylamide 
• 77004-72-9 Boc-rac-Lys(Z)-OtBu 
• 122546-52-5 N^α-tert-butyloxycarbonyl-N^ε-nicotinoyl-D-lysine 

Relevant articles and documents

DRUG-LOADED EMULSION

The present invention relates to a drug-loaded emulsion, comprising a modified hydrophobic excipient having the following formula, a hydrophobic drug and a surfactant: where R is a hydrophobic natural compound or a hydrophobic synthetic compound with one to three hydroxyl groups (n=1-3); and R1 is an α-amino protecting group, and R2 is an amino acid side chain, wherein, when m=0, R is reacted with an amino acid derivative with a protecting group by esterification to form a hydrophobic excipient carrying the amino acid derivative with a protecting group; or when m=1, R is firstly introduced with an amino acid linking arm of different chain lengths (l=1, 2, 4, 6) via an ester group, and then introduced with an amino acid derivative with a protecting group.

AGONISTS OF THE CHEMOKINE RECEPTOR CXCR3

The present invention relates to agonists of the chemokine receptor CXCR3, methods of their synthesis and uses thereof.

Concise total synthesis of aplysinellamides A and B

Concise and efficient total syntheses of bromotyrosine-derived metabolites aplysinellamides A and B, isolated from Australian marine sponge Aplysinella sp., have been accomplished in seven steps. A condensation between cinnamic acid and Boc-D-lysine methyl ester was applied to form the amide skeleton as a key step.