55894-18-3

Usage

Uses

Used in Pharmaceutical Industry:
ALLYL TRIBUTYLPHOSPHONIUM BROMIDE is used as an intermediate in the synthesis of quaternary phosphonium reversible inhibitors of cholinesterases for the treatment of various neurological disorders. These inhibitors play a crucial role in modulating the activity of cholinesterase enzymes, which are involved in the breakdown of acetylcholine, a neurotransmitter essential for cognitive functions and memory.
In addition to its use as an intermediate in the pharmaceutical industry, ALLYL TRIBUTYLPHOSPHONIUM BROMIDE may also have potential applications in other industries, such as:
1. Used in Chemical Synthesis:
ALLYL TRIBUTYLPHOSPHONIUM BROMIDE can be used as a starting material or a catalyst in various chemical reactions, including the synthesis of other quaternary phosphonium compounds, which have diverse applications in the chemical, pharmaceutical, and materials science industries.
2. Used in Material Science:
ALLYL TRIBUTYLPHOSPHONIUM BROMIDE may also find applications in the development of novel materials, such as ionic liquids, which have potential uses in energy storage, catalysis, and separation processes.
3. Used in Environmental Applications:
ALLYL TRIBUTYLPHOSPHONIUM BROMIDE could be employed in the treatment of wastewater or soil remediation, where its quaternary phosphonium structure may help in the removal of heavy metals or other contaminants.
4. Used in Analytical Chemistry:
ALLYL TRIBUTYLPHOSPHONIUM BROMIDE may also be used as a reagent or a reference material in analytical chemistry, particularly in the development of new methods for the detection and quantification of various analytes.

InChI:InChI=1/C15H32P.BrH/c1-5-9-13-16(12-8-4,14-10-6-2)15-11-7-3;/h8H,4-7,9-15H2,1-3H3;1H/q+1;/p-1

Upstream product

• 998-40-3 tributylphosphine 
• 106-95-6 allyl bromide 

Relevant academic research and scientific papers

Supramolecular Recognition of Quaternary Phosphonium Cations

The modes of supramolecular recognition of quaternary phosphonium cations mediated by 1,1′-bi-2-naphthol (BINOL) are identified and characterized. In contrast to our previous work on ammonium cations, the recognition of the quaternary phosphonium cations via the formation of a PR4+·Br–·BINOL ternary complex was found to be mediated by a hydrogen bond from an α-carbon center of the phosphonium cation, encapsulation within a continuous hydrogen bond network between the halide–BINOL network, or a combination of these effects working in tandem. The solid state structures of these ternary complexes were analyzed by X-ray crystallography, aided by Hirshfeld surface analysis, to confirm the presence of characteristic intermolecular interactions for the identified modes. In all cases, the quaternary phosphonium cation acts as a hydrogen bond donor (HBD) in these supramolecular interactions, and thus this is the key to the recognition process with BINOL. The characterization of such mechanisms offers insight into the supramolecular and crystal engineering communities in the future design of agents capable of the supramolecular recognition of phosphonium cations and their abstraction from the solution phase.

LSD1 INHIBITORS AND USES THEREOF

Provided are novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSDl. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSDl.

Polymerized phosphonium-based ionic liquids as stationary phases in gas chromatography: performance improvements by addition of graphene oxide

Eight new functionalized, polymerizable phosphonium ionic liquids were prepared and applied as polymeric stationary phases in gas chromatography (GC). These coated GC columns exhibit high thermal stability compared to other ionic liquids (220-380 °C), and column efficiencies between 2700 and 3700 plates per m. The new columns have been characterized using the Abraham model in order to understand the effects of the polymeric cations and anions on the behavior of the system. These stationary phases show unique selectivity for several types of organic compounds such as alcohols, amines, pesticides and polycyclic aromatic hydrocarbons (PAHs), with good peak symmetries in some cases. Moreover, graphene oxide (GO) sheets have been covalently bonded onto the inner wall surface of fused silica capillary columns using 3-aminopropyl-diethoxymethylsilane (3-AMDS) as a cross-linking agent. The use of GO in the preparation of the capillary columns enhances their efficiency, improving peak symmetries because of the reduction of the unspecific absorption.

High ion content siloxane phosphonium ionomers with very low T g

Polysiloxane phosphonium single-ion conductors grafted with oligomeric PEO and with ion contents ranging from 5 to 22 mol % were synthesized via hydrosilylation reaction. The parent Br- anion was exchanged to F- or bis(trifluoromethanesulfonyl)imide (TFSI-). X-ray scattering data suggest ion aggregation is absent in these phosphonium ionomers, which contributes to low glass transition temperatures (below -70 °C) with only a weak dependence on both ion content and counteranion type. Conductivities weakly increase with ion content but exhibit a strong dependence on anion type. The highest conductivity at 30 °C is 20 μS/cm for dry neat ionomer, with the TFSI- anion, consistent with its relatively delocalized negative charge and large size that weaken interactions between TFSI- and the phosphonium cation.

1H-NMR- AND MOESSBAUER INVESTIGATIONS ON THE ION PAIRS OF TETRACHLOROFERRATE(III) ANION WITH QUATERNARY PHOSPHONIUM CATIONS

Paramagnetic ion pairs were investigated by 1H-NMR and Moessbauer spectroscopy in chloroform and dimethyl sulphoxide.It has been shown that the chemical shifts of 1H-NMR peaks arise from a combination of contact and pseudocontact interactions of opposite sign, and the ratio of interactions was definitely influenced by the extent of solvation.On the basis of Moessbauer measurements it was shown that the change of the cation size had an effect on the electron delocalization and symmetry conditions of iron(III) in solid samples, too.In concentrated frozen solutions of ion pairs, different interactions were indicated by Moessbauer spectros copy in chloroform and dimethyl sulphoxide, in accordance with 1H-NMR results.However, in dilute solution such an anion-solvent interaction was observed directly, which could be shown by the NMR method only indirectly.