55899-13-3

Basic information

• Product Name: 1-amino-3-bromopyridin-1-ium 2,4,6-trimethylbenzene-1-sulfonate
• Synonyms: 1-amino-3-bromopyridin-1-ium 2,4,6-trimethylbenzene-1-sulfonate;1-Amino-3-bromopyridin-1-ium 2,4,6-trimethylbenzenesulfonate;3-Bromopyridin-1-ium-1-amine
• CAS NO: 55899-13-3
• Molecular Formula: C₅H₆BrN₂*C₉H₁₁O₃S
• Molecular Weight: 373.26538
• Mol File: 55899-13-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-amino-3-bromopyridin-1-ium 2,4,6-trimethylbenzene-1-sulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-amino-3-bromopyridin-1-ium 2,4,6-trimethylbenzene-1-sulfonate(55899-13-3)
• EPA Substance Registry System: 1-amino-3-bromopyridin-1-ium 2,4,6-trimethylbenzene-1-sulfonate(55899-13-3)

Safety Data

• Hazardous Substances Data: 55899-13-3(Hazardous Substances Data)

Usage

General Description

1-amino-3-bromopyridin-1-ium 2,4,6-trimethylbenzene-1-sulfonate is a complex organic compound that contains bromine and sulfur elements in its molecular structure. It inherits properties from both its constituents - the bromopyridinium cation and the trimethylbenzene-1-sulfonate making it a versatile compound with potential uses in a variety of chemical processes. Its designated Chemical Abstracts Service (CAS) registry number, which is a unique identifier for chemical substances, can be used to look up more specific details about its properties, reactions, and safety measures. The use and study of this substance is primarily in the field of chemical research and it is generally produced in controlled lab environments.

Upstream product

• 36016-39-4 N-(tert-butoxycarbonyl)-O-(mesitylsulfonyl)hydroxylamine 
• 626-55-1 3-Bromopyridine 
• 38202-27-6 ethyl O-(2-mesitylenesulfonyl)acetohydroxamate 
• 36016-40-7 mesitylenesulfonylhydroxylamine 

Downstream Products

• 2092153-80-3 4-bromopyrazolo[1,5-a]pyridine-3-carbonitrile 
• 2092835-01-1 6-bromopyrazolo[1,5-a]pyridine-3-carbonitrile 
• 55899-30-4 ethyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate 
• 1062368-71-1 methyl 4-bromopyrazolo[1,5-a]pyridine-3-carboxylate 
• 1062368-70-0 methyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate 
• 55899-29-1 ethyl 4-bromopyrazolo[1,5-a]pyridine-3-carboxylate 

Relevant articles and documents

Regioselective Synthesis of Pyrazolo[1,5- a]pyridine via TEMPO-Mediated [3 + 2] Annulation-Aromatization of N-Aminopyridines and α,β-Unsaturated Compounds

A TEMPO-mediated [3 + 2] annulation-aromatization protocol for the preparation of pyrazolo[1,5-a]pyridines from N-aminopyridines and α,β-unsaturated compounds was developed. The procedure offered multisubstituted pyrazolo[1,5-a]pyridines in good to excellent yield with high and predictable regioselectivity. The modification of marketed drugs including Loratadine, Abiraterone, and Metochalcone, and a one-pot three-step gram scale synthesis of key intermediate for the preparation of Selpercatinib were demonstrated. Mechanism studies show that TEMPO serves both as a Lewis acid and as an oxidant.

In Situ Preparation and Consumption of O -Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines

The paper demonstrates a safe method in which highly unstable O -mesitylsulfonylhydroxylamine (MSH) can be prepared and consumed in continuous flow. MSH was prepared in situ and used for the flow amination of a range of pyridines, which were subsequently transformed into useful pyrazolopyridine building blocks.

Structure-kinetics relations holding in the amination of six-membered nitrogen-containing heterocyclic compounds

Relative rates of the amination of 3-X- and 4-X-substituted pyridines (X = H, 3-Me, 4-Me, 3-F3C, 3-CN, 4-CN, 3-Cl, 3-Br, 4-MeO, 4-Me 2N), pyrazine, quinoline, isoquinoline, 2,2′- and 4,4′-bipyridines, and 1,10-phenanthroline with O-