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Kopsine is the major constituent of Kopsia tetrandra, a plant found in Southeast Asia. It is an alkaloid with a specific rotation of [α]D 17.5° (c 2.15, CHCl3). Kopsine forms a series of crystalline salts and derivatives, such as aurichloride, perchlorate, picrate, and methiodide. It can be reduced to its dihydro derivative, which has a melting point of 218°C. When fused with NaOH, kopsine yields 2-methylindole and 2-indole-2-carboxylic acid.

559-48-8

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559-48-8 Usage

Uses

Used in Pharmaceutical Industry:
Kopsine is used as a starting material for the synthesis of various alkaloids and pharmaceutical compounds due to its unique chemical properties and reactivity.
Used in Chemical Research:
Kopsine is used as a research compound for studying the chemical properties and reactions of alkaloids, as well as for understanding the structure and function of natural products derived from plants.
Used in Analytical Chemistry:
Kopsine and its derivatives can be used as reference compounds for the development and validation of analytical methods, such as chromatography and spectroscopy, for the identification and quantification of alkaloids in plant extracts and other samples.

References

Bhattacharya et al., 1. Amer. Chem. Soc., 71,3370 (1949) Spiteller et al., Naturwiss., 49, 279 (1962) Govindachari et al., Helv. Chim. Acta, 45, 1146 (1962) Govindachari et al., ibid, 46, 433, 572 (1963) Battersby, Gregory.,J. Chern. Soc., 22 (1963)

Check Digit Verification of cas no

The CAS Registry Mumber 559-48-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,5 and 9 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 559-48:
(5*5)+(4*5)+(3*9)+(2*4)+(1*8)=88
88 % 10 = 8
So 559-48-8 is a valid CAS Registry Number.
InChI:InChI=1/C22H24N2O4/c1-28-18(26)24-15-6-3-2-5-13(15)22-14-11-23-10-4-7-19(17(22)23)8-9-21(22,24)20(27,12-19)16(14)25/h2-3,5-6,14,17,27H,4,7-12H2,1H3/t14-,17+,19-,20-,21-,22+/m1/s1

559-48-8Downstream Products

559-48-8Relevant academic research and scientific papers

Synthesis of the Heptacyclic Indole Alkaloid (+/-)-Kopsine and Related Studies

Magnus, Philip,Katoh, Tadashi,Matthews, Ian R.,Huffman, John C.

, p. 6707 - 6711 (2007/10/02)

The synthesis of the heptacyclic indole alkaloid kopsine (1) was achieved by starting with the homoannular diene 14.Alkylation of the derived anion 15 with allyl bromide gave 16, which was converted into N1--10,22-di

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