55901-93-4Relevant academic research and scientific papers
BIOLOGICALLY ACTIVE THIONES DERIVED FROM PYRIDAZINONES
El-Hashash, M. A.,Soliman, F. M.,Amine, M. S.,Morsi, M.
, p. 299 - 304 (2007/10/02)
A number of pyridazin-3-thione (II), some hydrazinopyridazine derivatives (III) and its Schiff base (IV) have been prepared. α-(3-Thiopyridazinyl)-β-aroylpropionic acids (VI) have also been synthesized.Structural evidences are discussed.The antibacterial activity of these compounds has been studied.
Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
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, (2008/06/13)
Substituted 6-phenyl-3(2H)-pyridazinone compounds are useful as cardiotonic agents. Said compounds cause a significant increase in myocardial contractility in the anesthetized dog. Said compounds are produced by reacting substituted γ-oxobenzenebutanoic acids with suitably substituted hydrazines to provide 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are dehydrogenated to the desired product. The intermediate 6-phenyl-4,5-dihydro-3(2H)-pyridazinones are themselves useful as cardiotonic agents.
