55903-90-7Relevant academic research and scientific papers
Liphagal, a selective inhibitor of PI3 kinase α isolated from the sponge Aka coralliphaga: Structure elucidation and biomimetic synthesis
Marion, Frederic,Williams, David E.,Patrick, Brian O.,Hollander, Irwin,Mallon, Robert,Kim, Steven C.,Roll, Deborah M.,Feldberg, Larry,Van Soest, Rob,Andersen, Raymond J.
, p. 321 - 324 (2006)
Liphagal (1), a selective inhibitor of PI3K α, has been isolated from the marine sponge Aka coralliphaga collected in Dominica. The "liphagane" meroterpenoid carbon skeleton of liphagal (1) is new. A biomimetic total synthesis has been used to confirm the
MEROTERPENOID INHIBITORS OF PHOSPHOINOSITIDE 3 KINASE (PI3K)
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Page/Page column 29-32; 38-40, (2008/06/13)
Compounds with unique liphagane meroterpenoid carbon skeleton are described (structures I, II, III) together with pharmaceutical compositions and their use. A method of inhibiting the activity of phosphoinositide 3 kinase (PBK) is disclosed. In particular
Process for preparing polyene compounds
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, (2008/06/13)
Polyene compounds of the formula: EQU1 wherein R' is protected or unprotected hydroxyl or a group of the formula: EQU2 (in which R" and R"' are each carboxyl or a group convertible into carboxyl on hydrolysis), m is a positive integer and n is 0 or a positive integer, which are useful as intermediates in the synthesis of coenzyme Q, can be produced advantageously through a step for the dehydration of a compound of the formula: EQU3 wherein R', m and n are each as defined above.
