55917-03-8Relevant academic research and scientific papers
Direct Synthesis of Lactams from Keto Acids, Nitriles, and H2 by Heterogeneous Pt Catalysts
Siddiki,Touchy, Abeda S.,Bhosale, Ashvini,Toyao, Takashi,Mahara, Yuji,Ohyama, Junya,Satsuma, Atsushi,Shimizu, Ken-Ichi
, p. 789 - 795 (2018/02/27)
We report herein the first general catalytic system for the direct synthesis of N-substituted γ- and δ-lactams by reductive amination/cyclization of keto acids (including levulinic acid) with nitriles and H2 under mild conditions (7 bar H2, 110 °C, solvent free). The most effective catalyst, Pt and MoOx co-loaded TiO2 (Pt-MoOx/TiO2), shows a wide substrate scope, high turnover number (TON), and good reusability.
Cyclic sulfamidates as vehicles for the synthesis of substituted lactams
Bower, John F.,Svenda, Jakub,Williams, Andrew J.,Charmant, Jonathan P. H.,Lawrence, Ron M.,Szeto, Peter,Gallagher, Timothy
, p. 4727 - 4730 (2007/10/03)
(Chemical Equation Presented) A structurally diverse series of mono- and disubstituted 1,2- and 1,3-cyclic sulfamidates react with stabilized enolates, including malonate and phosphonoacetate variants, to provide, after lactamization, substituted and α-fu
ELECTROPHILIC OLEFIN HETEROCYCLIZATION IN ORGANIC SYNTHESIS. FORMATION OF δ-LACTAMS BY IODINE-INDUCED LACTAMIZATION OF δ,ε-UNSATURATED THIOIMIDATES
Takahata, Hiroki,Wang, Eng-Chi,Ikuro, Kazumi,Yamazaki, Takao,Momose, Takefumi
, p. 435 - 440 (2007/10/02)
The diastereoselective iodine-induced lactamization of δ,ε-unsaturated thioimidates (1) accessible from allylation of a dianion of N-benzyl-3-phenylsulfonylpropionamide (3) followed by elaboration gave the substituted δ-lactams (2).
