55927-20-3Relevant academic research and scientific papers
Trans-substitution and equilibration of phenols. Part IV. The influence of various catalysts on the trans-tert-butylation reaction of phenols; mechanistic aspects
Willemse, F. R. J.,Kooyman, E. C.,Lamoen, H. B. van,Vos, D. de,Wolters, J.
, p. 206 - 209 (2007/10/02)
The trans-tert-butylation reaction by 2,6-di-tert-butyl-4-methylphenol has been studied for a number of phenols in the presence of different catalysts.Equilibria, as well as reaction kinetics, have been investigated.The mechanism involves the intermediacy of a tert-butyl ether.This mechanism is supported both by the kinetics and the initially high ortho/para ratio as well as by the reversed substituent effect.
