55950-68-0

Usage

Uses

Used in Organic Synthesis:
(2-chloro-4-nitrophenyl)hydrazine is used as a reagent in organic synthesis, particularly for the formation of azo compounds. Its unique structure allows it to participate in various chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Dye Production:
As an intermediate, (2-chloro-4-nitrophenyl)hydrazine plays a crucial role in the production of dyes. Its ability to form azo compounds contributes to the creation of a wide range of dye colors, which are essential in various industries such as textiles, plastics, and printing.
Used in Pharmaceutical Industry:
(2-chloro-4-nitrophenyl)hydrazine is also utilized as an intermediate in the production of pharmaceuticals. Its involvement in the synthesis of various drug compounds highlights its importance in the development of new medications and therapies to treat a range of medical conditions.

InChI:InChI=1/C6H6ClN3O2/c7-5-3-4(10(11)12)1-2-6(5)9-8/h1-3,9H,8H2

Upstream product

• 350-30-1 3-chloro-4-fluoronitrobenzene 
• 121-87-9 2-Chloro-4-nitroaniline 

Downstream Products

• 79326-50-4 2-(2-Chloro-4-nitro-phenyl)-4-(2-chloro-4-nitro-phenylazo)-5-methyl-2,4-dihydro-pyrazol-3-one 
• 1374754-73-0 1,2-dimethyl-7,9-diphenyl-3H-pyrrolo[3,2-f]quinolin-4-yl chloride 
• 75912-42-4 Methyl-aethyl-keton-<2-chlor-4-nitro-phenylhydrazon> 
• 72791-01-6 2'-(2-chloro-4-nitrophenyl)-2,2-dimethylpropionohydrazide 
• 859300-37-1 2-(2-chloro-5-nitro-phenyl)-4-methyl-2H-phthalazin-1-one 

Relevant academic research and scientific papers

One-pot synthesis of pyrrolo[3,2-f]-and pyrrolo[2,3-h]quinoline derivatives: Observation of an unexpected mechanistic pathway

One-pot synthesis of pyrrolo[3,2-f]- and pyrrolo[2,3-h]quinolines were obtained starting from substituted 5-aminoindoles, benzaldehydes, and phenylacetylenes in the presence of La(OTf)3 as a catalyst in good yields. The indole moiety in 5-aminoindole is believed to be mainly responsible for the observation of unexpected mechanistic pathway to the formation of pyrrolo[2,3-h]quinoline. Georg Thieme Verlag Stuttgart · New York.

THIAZOLYL-DIHYDRO-INDAZOLE

The present invention relates to new thiazolyl-dihydro-indazoles of general formula (I) wherein the groups R1, R2 and R3 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-indazoles and the use thereof as pharmaceutical compositions.

Use of substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadizol-2-ones for inhibiting pancreatic lipase

The invention relates to a method for inhibiting pancreatic lipase, or the prophylaxis or treatment of obesity or diabetes mellitus of type 1 and 2, in a patient in need thereof, comprising administering to the patient a pharmaceutically effective amount of substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadiazol-2-ones of formula 1: wherein R1, R2, R3, R4 and R5 are as defined herein, or a prodrug, solvate, pharmacologically acceptable salt or acid addition salt thereof.

Substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, their preparation and their use as pharmaceuticals

Substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones of the formula 1 are described, in which R1 is substituted C1-C6-alkyl and C3-C9-cycloalkyl, R2, R3, R4 and R5 are hydrogen, halogen, nitro, C1-C4-alkyl, C1-C9-alkyloxy, substituted C6-C10-aryl-C1-C4-alkyloxy, C6-C10-aryloxy, C6-C10-aryl, C3-C8-cycloalkyl or O—C3—C8-cycloalkyl, or 2-oxopyrrolidin-1-yl, 2,5-dimethylpyrrol-1-yl or NR6-A-R7, with the proviso that R2, R3, R4 and R5 are not simultaneously hydrogen, and at least one of the radicals R2, R3, R4 or R5 is the radical 2-oxopyrrolidin-1-yl, 2,5-dimethylpyrrol-1-yl or NR6-A-R7, wherein R6=hydrogen, C1-C4-alkyl or substituted C6-C10-aryl-C1-C4-alkyl, A=a single bond, COn, SOn or CONH, n=1 or 2, R7=hydrogen, substituted C1-C18-alkyl, C2-C18-alkenyl, C6-C10-aryl-C1-C4-alkyl, C5-C8-cycloalkyl-C1-C4-alkyl, C5-C8-cycloalkyl, C6-C10-aryl-C2-C6-alkenyl, C6-C10-aryl, biphenylyl, biphenylyl-C1-C4-alkyl, indanyl, or the group Het-(CH2)r—, wherein r=0, 1, 2 or 3 and Het=a saturated or unsaturated 5-7-membered heterocycle, which may be optionally benzo-fused and optionally substituted, and proceses for their preparation. The compounds of formula 1 show an inhibitory effect on hormone-sensitive lipase, HSL.