55970-42-8

Basic information

• Product Name: 1H-Pyrrole-2-carboxaldehyde,1-methyl-,oxime(9CI)
• Synonyms: 1H-Pyrrole-2-carboxaldehyde,1-methyl-,oxime(9CI)
• CAS NO: 55970-42-8
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.14
• Product Categories: OXIME
• Mol File: 55970-42-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 223.1°Cat760mmHg
• Flash Point: 88.7°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 0.0562mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: 1H-Pyrrole-2-carboxaldehyde,1-methyl-,oxime(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboxaldehyde,1-methyl-,oxime(9CI)(55970-42-8)
• EPA Substance Registry System: 1H-Pyrrole-2-carboxaldehyde,1-methyl-,oxime(9CI)(55970-42-8)

Safety Data

• Hazardous Substances Data: 55970-42-8(Hazardous Substances Data)

Usage

Explanation

The compound consists of 6 carbon atoms, 8 hydrogen atoms, 2 nitrogen atoms, and 1 oxygen atom.

Explanation

The compound is derived from 1H-pyrrole-2-carboxaldehyde by the addition of an oxime group.

Explanation

A methyl group (CH3) is attached to the nitrogen atom in the compound.

Explanation

The compound is used as a building block for the preparation of various heterocyclic compounds and pharmaceuticals.

Explanation

Due to its unique structure and properties, the compound has potential applications in the development of new drugs and as a reagent in various chemical reactions.

Explanation

The compound's structure and properties make it valuable for the study of organic chemistry and the development of new materials.

Oxime derivative

1H-pyrrole-2-carboxaldehyde

Methyl group attachment

Nitrogen atom

Usage

Organic synthesis and research

Potential applications

Development of new drugs and as a reagent in chemical reactions

Value in study and material development

Organic chemistry and new materials

InChI:InChI=1/C6H8N2O/c1-8-4-2-3-6(8)5-7-9/h2-5,9H,1H3

Upstream product

• 1192-58-1 N-methylpyrrole aldehyde 
• 1003-29-8 2-pyrrole aldehyde 

Downstream Products

• 69807-81-4 2-aminomethyl-1-methyl-1H-pyrrole 
• 89488-02-8 1-methyl-4-nitro-pyrrolecarbonitrile 

Relevant articles and documents

Radical-anion coupling through reagent design: hydroxylation of aryl halides

The design and development of an oxime-based hydroxylation reagent, which can chemoselectively convert aryl halides (X = F, Cl, Br, I) into phenols under operationally simple, transition-metal-free conditions is described. Key to the success of this approach was the identification of a reducing oxime anion which can interact and couple with open-shell aryl radicals. Experimental and computational studies support the proposed radical-nucleophilic substitution chain mechanism.

Discovery of novel heteroarylmethylcarbamodithioates as potent anticancer agents: Synthesis, structure-activity relationship analysis and biological evaluation

A series of new analogs based on the structure of lead compound 10 were designed, synthesized and evaluated for their in vitro anti-cancer activities against four selected human cancer cell lines (HL-60, Bel-7402, SK-BR-3 and MDA-MB-468). Several synthesized compounds exhibited improved anti-cancer activities comparing with lead compound 10. Among them, 1,3,4-oxadiazole analogs 17o showed highest bioactivity with IC50 values of 1.23, 0.58 and 4.29 μM against Bel-7402, SK-BR-3 and MDA-MB-468 cells, respectively. It is noteworthy that 17o has potent anti-proliferation activity toward a panel of cancer cells with relatively less cytotoxicity to nonmalignant cells. The further mechanistic study showed that it induced apoptosis and cell cycle arrest through disrupting spindle assembly in mitotic progression, indicating these synthesized dithiocarbamates represented a novel series of anti-cancer compounds targeting mitosis.

Synthesis of platinum complexes of 2-aminomethylpyrrolidine derivatives for use as carrier ligands and their antitumor activities

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