55989-13-4

Usage

Uses

Used in Pharmaceutical Synthesis:
3-(4-chlorophenyl)piperidine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new medicinal compounds.
Used in Research Chemicals:
It serves as a research chemical, aiding in the exploration and understanding of chemical reactions and properties of related compounds in the field of medicinal chemistry.
Used in Organic Synthesis:
3-(4-chlorophenyl)piperidine is used as a reagent in organic synthesis, facilitating the creation of new chemical entities and enhancing the scope of chemical research.
Used in Chemical Compound Development:
It is utilized in the development of novel chemical compounds, potentially leading to advancements in various chemical and pharmaceutical applications.
It is crucial to handle 3-(4-chlorophenyl)piperidine with care due to its potential health hazards, ensuring adherence to safety guidelines and procedures to mitigate risks during its use in these applications.

InChI:InChI=1/C11H14ClN/c12-11-5-3-9(4-6-11)10-2-1-7-13-8-10/h3-6,10,13H,1-2,7-8H2

Upstream product

• 140-53-4 p-chlorobenzyl cyanide 
• 885693-20-9 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 1018699-96-1 tert-butyl 3-(4-chlorophenyl)piperidine-1-carboxylate 
• 106-39-8 bromochlorobenzene 

Downstream Products

• 1187318-68-8 1-benzyl-3-(4-chlorophenyl)piperidine 
• 1602923-16-9 (4-chlorophenyl)-carbamic acid 1-[3-(4-chlorophenyl)-piperidin-1-ylmethyl]-2,2,2-trifluoro ethyl ester 
• 1602924-08-2 3-(3-(4-chlorophenyl)piperidin-1-yl)-1,1,1-trifluoropropan-2-ol 
• 1187318-69-9 diphenylmethanone [4-(1-benzylpiperidin-3-yl)phenyl]hydrazone 
• 1106937-63-6 3-(4-chlorophenyl)-1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidine 
• 945978-25-6 2-chloro-4-[3-(4-chlorophenyl)-piperidin-1-yl]-[1, 3, 5]triazine 

Relevant academic research and scientific papers

Synthesis method of (S)-3-(4-chlorophenyl)-piperidine

The invention relates to a synthetic method of (S)-3-(4-chlorophenyl)-piperidine. The invention mainly aims to solve the technical problems of harsh reaction conditions, expensive catalysts, high cost, unsuitability for large-scale production and the like when optically pure (S)-3-(4-chlorophenyl)-piperidine is prepared by hydrogenating a pyridine ring and then utilizing chiral SFC. The synthesis method comprises the following four steps: (1) alpha-site alkylation of 4-chlorobenzyl cyanide; (2) reduction of 5-chloro-2-(4-chlorophenyl)valeronitrile; (3) cyclization of the 5-chloro-2-(4-chlorphenyl)amyl-1-amine to obtain (RS)-3-(4-chlorophenyl)-piperidine; and (4) chemical resolution of the (RS)-3-(4-chlorophenyl)-piperidine to obtain a final product. A target product with an optical purity reaching 98% or above is obtained through four-step reaction. The method is high in yield, low in cost, simple and convenient to operate and purify, good in economic benefits and more suitable for industrial production.

QUATERNARY LACTAM COMPOUND AND PHARMACEUTICAL USE THEREOF

A quaternary lactam compound of formula (I). The compound is used in the manufacture of a medicament for the treatment and/or prevention of thrombotic or thromboembolic disorders.