55990-92-6

Upstream product

• 14665-49-7 4,4'-disulfanediyl-di-resorcinol 
• 77-78-1 dimethyl sulfate 
• 2735-04-8 2,4-Dimethoxyaniline 
• 151-10-0 1,3-Dimethoxybenzene 
• 18906-37-1 2,4-dimethoxybenzenethiol 
• 160855-21-0 N-(2,4-dimethoxyphenylthio)phthalimide 

Downstream Products

• 117038-93-4 2-(2,4-dimethoxyphenylthiomethyl)tetrahydrofuran 
• 117038-94-5 2-(2,4-dimethoxyphenylthiomethyl)-2,3-dihydrobenzofuran 

Relevant academic research and scientific papers

Selenosilane-Promoted Selective Mild Transformation of N -Thiophthalimides into Symmetric Disulfides

The reactivity of N -thiophthalimides with silyl chalcogenides is described. Treatment of N -thiophthalimides with bis(trimethylsilyl) sulfide [(Me 3 Si) 2 S] leads to the formation of a mixture of the corresponding disulfides and tr

New Inhibitors of Indoleamine 2,3-Dioxygenase 1: Molecular Modeling Studies, Synthesis, and Biological Evaluation

Indoleamine 2,3-dioxygenase 1 (IDO1) is an attractive target for anticancer therapy. Herein, we report a virtual screening study which led to the identification of compound 5 as a new IDO1 inhibitor. In order to improve the biological activity of the identified hit, arylthioindoles 6-30 were synthesized and tested. Among these, derivative 21 exhibited an IC50 value of 7 μM, being the most active compound of the series. Furthermore, compounds 5 and 21 induced a dose-dependent growth inhibition in IDO1 expressing cancer cell lines HTC116 and HT29. Three-dimensional quantitative structure-activity relationship studies were carried out in order to rationalize obtained results and suggest new chemical modifications.

Phthalimidesulfenyl chloride. x1. a synthetic equivalent of hs+ and+s-s+ species in electrophilic aromatic substitutions

The reaction of phthalimidesulfenyl chloride, 1, with activated arenes provides monosubstituted phthalimidesulfenyl derivatives 3 which can be easily transformed into the corresponding disulfides 7, thiols 8 and masked thiols 9.