56009-30-4Relevant academic research and scientific papers
Rhodium(II)-catalyzed c-h functionalization of electron-deficient methyl groups
Fu, Liangbing,Guptill, David M.,Davies, Huw M. L.
, p. 5761 - 5764 (2016/06/08)
Enantioselective C-H functionalization of relatively electron-deficient methyl sites was achieved with the combination of 2,2,2-trichloroethyl aryldiazoacetates and tetrakis(triarylcyclopropanecarboxylate) dirhodium catalysts. The substrate scope of the transformation was relatively broad, and C-H functionalization products were furnished with excellent levels of enantioselectivity. As a strategic reaction, crotonate derivatives give 1,6-dicarbonyl compounds, which are useful for further diversification.
