5601-74-1 Usage
Description
Ophiobolin B is a sesterterpenoid fungal phytotoxin that is a minor member of a class of phytotoxic metabolites produced by Bipolaris and other genera of plant pathogenic fungi. It acts by inhibiting calmodulin action in calcium regulation, which is a calcium-sensing protein that regulates a wide array of proteins involved in diverse cellular functions.
Uses
Used in Anticancer Applications:
Ophiobolin B is used as an anticancer agent for inducing apoptosis in chronic lymphocytic leukemia cells with an LC50 value of 2 nM. It modulates several oncological signaling pathways, exerting inhibitory effects on tumor growth and progression.
Used in Antimicrobial Applications:
Ophiobolin B is used as an antimicrobial agent, exhibiting cytotoxic and antimicrobial effects against different zygomycetes with MIC values ranging from 25-50 μg/ml.
Used in Agricultural Industry:
Ophiobolin B is used as a fungal phytotoxin for inhibiting calmodulin, a protein involved in calcium regulation, which helps in controlling plant pathogenic fungi and protecting crops from diseases.
Used in Pharmaceutical Industry:
Ophiobolin B is used as a potential pharmaceutical candidate due to its ability to bind and irreversibly antagonize calmodulin, which can be utilized in the development of new drugs targeting various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 5601-74-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,6,0 and 1 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 5601-74:
(6*5)+(5*6)+(4*0)+(3*1)+(2*7)+(1*4)=81
81 % 10 = 1
So 5601-74-1 is a valid CAS Registry Number.
