56010-53-8Relevant academic research and scientific papers
Selective aldehyde reduction in ketoaldehydes with NaBH4-Na 2CO3-H2O at room temperatures
Chandrasekhar, Sosale,Shrinidhi, Annadka
, p. 2051 - 2056 (2014/07/07)
A variety of aliphatic and aromatic ketoaldehydes were reduced to the corresponding ketoalcohols with a mixture of sodium borohydride (1.2 equivalents) and sodium carbonate (sixfold molar excess) in water. Reactions were performed at room temperatures(typically) 2 h, and yields of isolated products generally ranged from 70% to 85%. A bis-carbonate-borane complex, [(BH3)2CO2]2- 2Na+, possibly formed from the reagent mixture, is likely the active reductant. The moderated reactivity of this acylborane species would explain the chemoselectivity observed in the reactions. The readily available reagents and the mild aqueous conditions make for ease of operation and environmental compatibility, and make a useful addition to available methodology. Copyright
