56012-64-7Relevant academic research and scientific papers
Reaction of 2-phenyl substituted 1,2,3-triazol 1-oxides with acylating agents. Preparation of hydroxy- halogen- hydroxymethyl- and chloromethyltriazoles
Begtrup, Mikael
, p. 717 - 728 (2007/10/03)
2-Phenyltriazol 1-oxides react with acetyl chloride producing acetoxy- and chloro-substituted triazoles.The substituents enter the 5 and the 4-position.When these are not accessible the substituents go to lateral positions and to the phenyl group producing acetoxymethyltriazoles and 2-halogenophenyl triazoles.Acetic anhydride reacts reluctantly while trifluoroacetic anhydride is more reactive producing trifluoroacetoxytriazoles.The reactions provide effective routes to hydroxy- and hydroxymethyltriazoles.Several mechanisms among which a cyclic one are operating.
HYDROXY-1,2,3-TRIAZOLES. I. SOME CHARACTERISTICS OF 4-HYDROXY-1,2,3-TRIAZOLES
Kirillova, L. P.,Shul'gina, V. M.,Gareev, G. A.,Sitchikhina, L. G.,Vereshchagin, L. I.
, p. 589 - 594 (2007/10/02)
Some chemical characteristics of 2-phenyl-4-hydroxy-1,2,3-triazole and the corresponding N-oxide were investigated.It was shown that the nitration and halogenation of these compounds takes place at position 5 of the triazole ring and alkylation and acylation take place at the hydroxyl group with the formation of ethers and esters.In vinyl exchange reactions with vinyl acetate the hydroxytriazole N-oxide gives the N-vinyl derivative, while the hydroxytriazole gives triazolyl vinyl ether.
Process for the preparation of 2-phenyl-4-hydroxy-1,2,3-triazole-1-oxides
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, (2008/06/13)
Process for the preparation of 2-phenyl-4-hydroxy-1,2,3-triazole-1-oxides of the formula STR1 from oxime-hydrazones of the formula STR2 in which formulae R stands for an unsubstituted or substituted phenyl group.
