560132-50-5Relevant academic research and scientific papers
Synthesis of original trifluoromethylated 6-aryl-pyridazines fused with thiazolidine or 1,2,4-triazole
Brule, Cedric,Bouillon, Jean-Philippe,Nicolai, Eric,Portella, Charles
, p. 103 - 106 (2007/10/03)
An efficient synthesis of original 8-trifluoromethyl-7H-thiazolo[3,2-b]-and 1,2,4-triazolo[4,3-b]pyridazines is described. Starting from the 4-trifluoromethyl-4,5-dihydropyridazin-3-one, the methodology involves a five-membered ring closure, based on the
Fluorinated ketene dithioacetals. Part 10. Synthesis of new perfluorinated (2H)-pyridazin-3-ones and 3-(alkyl- or arylamino) substituted pyridazines
Brule, Cedric,Bouillon, Jean-Philippe,Nicolai, Eric,Portella, Charles
, p. 436 - 442 (2007/10/03)
α-Trifluoromethyl γ-keto thiolesters 4a and 7, obtained from the corresponding perfluoroketene dithioacetals 3a, led in a two-step sequence (condensation with hydrazine - dehydrogenation reaction) to the (2H)-pyridazin-3-ones 9a,c-e. Subsequent chlorinati
