56063-16-2

Upstream product

• 40290-63-9 Methyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 56063-15-1 Boc-Phe-Met-NH₂ 

Downstream Products

• 82816-81-7 Boc-Tyr-Phe-Gly-Phe-Met-NH₂ 
• 82816-85-1 HCl*Tyr-Phe-Gly-Phe-Met-NH₂ 
• 82816-84-0 HCl*Phe-Tyr-Gly-Phe-Met-NH₂ 
• 82816-83-9 HCl*Phe-Phe-Gly-Phe-Met-NH₂ 

Relevant academic research and scientific papers

SYNTHESIS OF PENTAPEPTIDES RELATED BOTH TO SUBSTANCE P C-TERMINAL FRAGMENT AND MET-ENKEPHALIN

Six pentapeptide amides related both to Substance P C-terminal fragment and to Met-enkephalin have been synthesized.Syntheses were effected by coupling fragments 3 + 2 in solution.The DCC + HOBt method was used for synthesis of peptide fragments and final

Analgesic compounds

Compounds of the formula STR1 and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D, when applicable, define the chirality; R1 is hydrogen, C1 -C3 primary alkyl, or allyl; R2 is hydrogen or C1 -C3 primary alkyl, subject to the limitation that when R1 is allyl, R2 is hydrogen; R3 is hydrogen or C1 -C3 primary alkyl; R4 is C1 -C4 primary or secondary alkyl; R5 is hydrogen or C1 -C4 primary or secondary alkyl; R6 is hydrogen or C1 -C3 primary alkyl; R7 is hydrogen or C1 -C3 primary alkyl; Y is hydrogen or acetyl; Z is hydrogen of STR2 in which R8 is C1 -C3 alkyl or hydrogen; and W is isopropyl, --VR9, or --CH2 --X--CH3, in which V is O or S, R9 is C1 -C4 alkyl or aralkyl, and X is O, S, or --CH2 --, subject to the limitation that, when W is isopropyl, R7 is C1 -C3 primary alkyl; are useful analgesic agents.