56070-94-1Relevant academic research and scientific papers
Synthesis of Guineensine, an Alkaloid Isolated from the Fruits of Piper guineense and P. officinarum
Vig, O. P.,Sharma, S. D.,Sood, O. P.,Bari, S. S.
, p. 350 - 352 (2007/10/02)
Wittig reaction of 8-(tetrahydro-2'-pyranyloxy)octanal (IV) with (3',4'-methylenedioxyphenyl)triphenylphosphonium bromide yields 9-(3',4'-methylenedioxyphenyl)-1-(tetrahydro-2''-pyranyloxy)non-8-trans-ene (V).V on treatment with PTS in methanol followed by subsequent oxidation with pyridinium chlorochromate affords 9-(3',4'-methyleneedioxyphenyl)non-8-trans-en-1-al (VII).VII on modified Wittig reaction with ethyl α-diethylphosphonocrotonate gives the conjugate ester (VIII) which on alkaline hydrolysis provides 13-(3',4'-methylendioxyphenyl)trideca-2,4,12-trans,trans,trans-trienoic acid (IX).IX on condensation with N-isobutylamine using POCl3 in the presence of triethylamine furnishes I.
