56072-03-8

Usage

InChI:InChI=1/C10H12N2O2/c1-7(12-14)9-3-5-10(6-4-9)11-8(2)13/h3-6,14H,1-2H3,(H,11,13)/b12-7-

Upstream product

• 2719-21-3 4-(N-acetylamino)acetophenone 

Downstream Products

• 2719-21-3 4-(N-acetylamino)acetophenone 
• 140-50-1 N,N'-diacetyl-1,4-phenylenediamine 
• 62731-27-5 C₁₂H₁₄N₂O₃ 
• 1260236-30-3 N-(1-(4-acetamidophenyl)vinyl)acetamide 
• 1090461-78-1 C₁₂H₁₂N₂O₂ 

Relevant academic research and scientific papers

Copper-Catalyzed Annulation of Oxime Acetates with α-Amino Acid Ester Derivatives: Synthesis of 3-Sulfonamido/Imino 4-Pyrrolin-2-ones

A copper-catalyzed annulation of oxime acetates and α-amino acid ester derivatives for the easy preparation of 4-pyrrolin-2-ones bearing a 3-amino group has been developed. This process features the oxidation of amines with oxime esters as the internal oxidant to produce the active 1,3-dinucleophilic and 1,2-dielectrophilic species concurrently. The subsequent nucleophilic cyclization realizes the efficient construction of 4-pyrrolin-2-one derivatives.

Synthesis of β-blocking oximes. Influence of terminal amine on β-selectivity

Three series of oximinopropanolamine derivatives in which the terminal nitrogen has been substituted by various arylalkyl groups were synthesized. The beta-adrenergic blocking activity of the 21 compounds was determined in vitro on the guinea-pig. The structure-activity relationship is discussed.