56073-18-8

Upstream product

• 852460-34-5 2-biphenyl-4-yl-chroman-4-ol 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 3218-36-8 4-Phenylbenzaldehyde 
• 41255-15-6 (E)-3-([1,1′-biphenyl]-4-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one 
• 41255-26-9 2-([1,1′-biphenyl]-4-yl)chroman-4-one 
• 118-93-4 o-hydroxyacetophenone 

Relevant academic research and scientific papers

Design and synthesis of novel diphenacoum-derived, conformation-restricted vitamin K 2,3-epoxide reductase inhibitors

Two novel diphenacoum-derived analogues 5 and 6 are designed, synthesized and tested as potential vitamin K 2,3-epoxide reductase (VKOR) inhibitors. The inhibition studies indicated that 5 is a potent VKOR inhibitor, which confirmed that the replacement of the tetrahydronaphthalene on diphenacoum to a chroman functionality does not have a major impact on inhibition potency. The conformation-restricted compound 6 is a moderate inhibitor which may serve as a lead compound for further study of the mode of action of coumarin-type anticoagulants at the molecular level.