56073-95-1

Usage

Uses

Used in Pharmaceutical Industry:
[5-[[4-(Acetylamino)phenyl]thio]-1H-benzimidazol-2-yl]-carbamic acidmethylester is used as a potential pharmaceutical compound for its structural similarity to other bioactive molecules, which may indicate possible therapeutic applications. Further research is needed to explore its efficacy and safety in treating specific medical conditions.
Used in Research and Development:
In the field of chemical research and development, [5-[[4-(Acetylamino)phenyl]thio]-1H-benzimidazol-2-yl]-carbamic acidmethylester serves as a valuable compound for studying its chemical properties, reactivity, and potential interactions with biological systems. This research could lead to the discovery of new drugs or therapeutic approaches.
Used in Drug Design and Synthesis:
[5-[[4-(Acetylamino)phenyl]thio]-1H-benzimidazol-2-yl]-carbamic acidmethylester is used as a building block or template in drug design and synthesis, owing to its unique structural features. It may be modified or combined with other molecules to create new pharmaceutical agents with improved efficacy and selectivity for various diseases and conditions.

InChI:InChI=1/C17H16N4O3S/c1-10(22)18-11-3-5-12(6-4-11)25-13-7-8-14-15(9-13)20-16(19-14)21-17(23)24-2/h3-9H,1-2H3,(H,18,22)(H2,19,20,21,23)

Upstream product

• 1635-61-6 5-chloro-2-nitroaniline 
• 56073-93-9 5-(4-acetamidothiophenoxy)-2-nitroaniline 
• 1126-81-4 4-acetamidothiophenol 
• 34840-23-8 1,3-Dicarbomethoxy-S-methylisothiourea 
• 56073-94-0 N-[4-(3,4-diaminophenylsulfanyl)phenyl]acetamide 

Downstream Products

• 97849-26-8 2-amino-5⁽⁶⁾-(4-aminophenylthio)benzimidazole 
• 97849-12-2 [5-(4-Acetylamino-benzenesulfonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester 
• 56073-96-2 methyl N-[5⁽⁶⁾-(4-aminophenylsulfanyl)benzimidazol-2-yl]carbamate 
• 97849-27-9 5-(4-Amino-benzenesulfonyl)-1H-benzoimidazol-2-ylamine 
• 97849-29-1 [5-(4-Isothiocyanato-phenylsulfanyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester 
• 97849-24-6 [5-(4-Amino-benzenesulfonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester 
• 97849-30-4 [5-(4-Isothiocyanato-benzenesulfonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester 
• 433224-15-8 C₂₃H₁₇F₄N₅O₄S 
• 433224-09-0 C₂₃H₁₇F₄N₅O₃S 

Relevant academic research and scientific papers

Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors

We herein disclose a novel chemical series of benzimidazole-ureas as inhibitors of VEGFR-2 and TIE-2 kinase receptors, both of which are implicated in angiogenesis. Structure-activity relationship (SAR) studies elucidated a critical role for the N1 nitrogen of both the benzimidazole (segment E) and urea (segment B) moieties. The SAR results were also supported by the X-ray crystallographic elucidation of the role of the N1 nitrogen and the urea moiety when the benzimidazole-urea compounds were bound to the VEGFR-2 enzyme. The left side phenyl ring (segment A) occupies the backpocket where a 3-hydrophobic substituent was favored for TIE-2 activity.

Syntheses and Anthelmintic Activity of 2-Substituted 5(6)-Arylthio- and 5(6)-Arylsulphono-benzimidazoles

A series of 2-substituted 5(6)-arylthio- and 5(6)-arylsulphono-benzimidazoles (7-32) have been prepared and tested for their anthelmintic activity.Among the compounds tested against Hymenolepis nana infection in rats and mice and Ancylostoma ceylanicum in