56092-82-1 Usage
Uses
Used in Research and Development:
IONOMYCIN CALCIUM SALT is used as a calcium ionophore for research on Ca++ transport across biological membranes. It is particularly effective in increasing intracellular Ca2+ concentration, making it a valuable tool for various cell activation experiments.
Used in Pharmaceutical Applications:
IONOMYCIN CALCIUM SALT is used as an apoptotic degeneration inducer for inducing apoptotic degeneration of embryonic cortical neurons and cell cycle arrest at the G1 phase. It is more effective than A23187 (sc-3591) and provides a useful tool for studying cell cycle regulation and apoptosis.
Used in Immunology:
IONOMYCIN CALCIUM SALT is used as a T cell activator and cytokine inducer in the field of immunology. When combined with phorbol 12-myristate 13-acetate (PMA), it is commonly used to induce the proliferation and activation of T cells, as well as to stimulate cytokine production in macrophages in vitro.
Used in Cell Biology:
IONOMYCIN CALCIUM SALT is used as a tool in cell biology to study the effects of increased intracellular calcium levels on various cellular processes, such as cell signaling, cell differentiation, and cell death.
Used in Drug Delivery Systems:
IONOMYCIN CALCIUM SALT can be employed in the development of novel drug delivery systems to enhance its applications and efficacy in various fields, such as cancer research and immunology. The use of organic and metallic nanoparticles as carriers for Ionomycin calcium salt delivery can improve its bioavailability and therapeutic outcomes.
Biochem/physiol Actions
Product does not compete with ATP.
References
Liu et al. (1978), Ionomycin, a new polyether antibiotic; J. Antibiot., 31 815
Liu and Hermann et al. (1978), Characterization of ionomycin as a calcium ionophore; J. Biol.Chem, 253 5892
Check Digit Verification of cas no
The CAS Registry Mumber 56092-82-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,0,9 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 56092-82:
(7*5)+(6*6)+(5*0)+(4*9)+(3*2)+(2*8)+(1*2)=131
131 % 10 = 1
So 56092-82-1 is a valid CAS Registry Number.
InChI:InChI=1/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1
