561017-59-2Relevant academic research and scientific papers
1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors
Goeminne,McNaughton,Bal,Surpateanu,Van der Veken,De Prol,Versees,Steyaert,Apers,Haemers,Augustyns
, p. 2523 - 2526 (2008/02/05)
A range of novel 1,2,3-triazolylalkylribitol derivatives were synthesized and evaluated as nucleoside hydrolase inhibitors. The most active compound (11a) has low micromolar potency and is structurally diverse from previously reported nucleoside hydrolase
Synthesis of bridged sugar amino acids: A new entry into conformationally locked δ- and ε-amino acids
Van Well, Renate M.,Meijer, Marlies E. A.,Overkleeft, Herman S.,Van Boom, Jacques H.,Van Der Marel, Gijsbert A.,Overhand, Mark
, p. 2423 - 2434 (2007/10/03)
The synthesis of three methylene bridged sugar amino acids is described. Key transformations in the synthetic strategy are a CO-insertion on fully protected ribose, an aldol condensation with formaldehyde and an oxetane forming cyclisation step. A novel L
