561017-92-3Relevant academic research and scientific papers
Synthesis of bridged sugar amino acids: A new entry into conformationally locked δ- and ε-amino acids
Van Well, Renate M.,Meijer, Marlies E. A.,Overkleeft, Herman S.,Van Boom, Jacques H.,Van Der Marel, Gijsbert A.,Overhand, Mark
, p. 2423 - 2434 (2007/10/03)
The synthesis of three methylene bridged sugar amino acids is described. Key transformations in the synthetic strategy are a CO-insertion on fully protected ribose, an aldol condensation with formaldehyde and an oxetane forming cyclisation step. A novel L
