561041-07-4

Upstream product

• 1533518-92-1 (R)-2-butoxycarbonylamino-3-(4-ethoxyphenyl)propionic acid 
• 1417694-04-2 (R)-2-amino-3-(4-ethoxyphenyl)propionic acid hydrochloride 
• 501-53-1 benzyl chloroformate 
• 76757-92-1 (R)-2-((tert-butoxycarbonyl)amino)-3-(4-ethoxyphenyl)propanoic acid 
• 127419-60-7 (R)-2-amino-3-(4-ethoxy-phenyl)-propionic acid 

Downstream Products

• 1417694-05-3 [(R)-1-{(S)-1-[4-(tert-butoxycarbonylamino-methyl)-benzylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-(4-ethoxy-phenyl)-ethyl]-carbamic acid benzyl ester 
• 1417694-06-4 [(R)-1-{(S)-1-[4-(tert-butoxycarbonylaminomethyl)benzylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-(4-ethoxyphenyl)ethyl]carbamic acid benzyl ester 
• 1417694-07-5 [4-({(S)-2-[(R)-2-benzoylamino-3-(4-ethoxy-phenyl)-propionylamino]-3-phenyl-propionylamino}-methyl)-benzyl]-carbamic acid tert-butyl ester 
• 1417694-08-6 N-[(R)-1-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-(4-ethoxy-phenyl)-ethyl]-benzamide hydrochloride 

Relevant academic research and scientific papers

POLYMORPHS OF|N-[(R)-1 -[(S)-1-(4-AMINOMETHYL-BENZYLCARBAMOYL)-2-PHENYL-ETHYLCARBAMOY L]-2-(4-E|THOXY-PHENYL)-ETHYL]-BENZAMIDE HYDROCHLORIDE

The invention provides new polymorphs of N-[(R)-l-[(S)-l-(4-aminomethyl- benzylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-(4-ethoxy-phenyl)-ethyl]-benzamide hydrochloride, pharmaceutical compositions containing them and their use in therapy.

BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN

The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R1 to R9 are as defined herein.