56108-12-4

Usage

Uses

Used in Pharmaceutical Industry:
4-TERT-BUTYLBENZAMIDE is used as an intermediate for the synthesis of various pharmaceuticals, contributing to the development of new medications and improving existing ones. Its role in the synthesis process is crucial for creating a range of therapeutic agents.
Used in Organic Synthesis:
As a reagent in organic synthesis, 4-TERT-BUTYLBENZAMIDE is used for the preparation of functionalized derivatives of benzamides. This application is vital for the creation of complex organic molecules and compounds with specific properties and uses.
Used in Pesticide Production:
4-TERT-BUTYLBENZAMIDE is used as a building block in the production of pesticides, playing a key role in the development of effective and safe agricultural chemicals to protect crops and enhance yields.
Used in Dye Manufacturing:
In the dye industry, 4-TERT-BUTYLBENZAMIDE is utilized in the manufacturing process of various dyes. Its contribution is essential for producing a wide array of colorants used in different applications, including textiles, plastics, and printing inks.
Used in the Production of Other Organic Chemicals:
4-TERT-BUTYLBENZAMIDE also serves as a fundamental component in the production of other organic chemicals, highlighting its versatility and importance in the chemical industry.

InChI:InChI=1/C11H15NO/c1-11(2,3)9-6-4-8(5-7-9)10(12)13/h4-7H,1-3H3,(H2,12,13)

Upstream product

• 877-65-6 p-tert-butylbenzyl alcohol 
• 32857-63-9 4-t-butylphenylacetic acid 
• 943-27-1 4'-t-butylacetophenone 
• 15226-74-1 dicobalt octacarbonyl 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 7364-19-4 4-ethyl-tert-butylbenzene 
• 4210-32-6 4-tert-butyl benzonitrile 
• 98-51-1 4-tert-butyltoluene 
• 1710-98-1 p-tert-butyl benzoyl chloride 
• 201230-82-2 carbon monoxide 
• 35779-04-5 1-tert-butyl-4-iodobenzene 
• 3651-81-8 4-(tert-butyl)benzoyl azide 
• 3972-56-3 4-(tert-butyl)chlorobenzene 
• 253185-03-4 tert-butylbenzene 

Downstream Products

• 4210-32-6 4-tert-butyl benzonitrile 
• 91563-74-5 N-hydroxymethyl-p-tert-butylbenzamide 
• 132981-23-8 4-tert-butylbenzoyl isocyanate 
• 57774-77-3 4-t-butyl phenyl thioamide 
• 79097-97-5 1-(2-Amino-5-tert-butyl-phenyl)-2,2-dimethoxy-ethanone 
• 701-30-4 1-tert-butyl-4-fluorobenzene 
• 703-09-3 β-(4-Fluor-phenyl)-isobutylchlorid 
• 707-64-2 3-(4-fluorophenyl)-3-methylbutyraldehyde 
• 1050349-33-1 N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-N'-(4-tert-butylbenzoyl)urea 
• 1050349-36-4 N-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-N'-(4-tert-butylbenzoyl)urea 
• 1361875-82-2 4-tert-butyl-N-(4-tert-butylbenzyl)benzamide 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 

Relevant academic research and scientific papers

A “universal” catalyst for aerobic oxidations to synthesize (hetero)aromatic aldehydes, ketones, esters, acids, nitriles, and amides

Functionalized (hetero)aromatic compounds are indispensable chemicals widely used in basic and applied sciences. Among these, especially aromatic aldehydes, ketones, carboxylic acids, esters, nitriles, and amides represent valuable fine and bulk chemicals, which are used in chemical, pharmaceutical, agrochemical, and material industries. For their synthesis, catalytic aerobic oxidation of alcohols constitutes a green, sustainable, and cost-effective process, which should ideally make use of active and selective 3D metals. Here, we report the preparation of graphitic layers encapsulated in Co-nanoparticles by pyrolysis of cobalt-piperazine-tartaric acid complex on carbon as a most general oxidation catalyst. This unique material allows for the synthesis of simple, functionalized, and structurally diverse (hetero)aromatic aldehydes, ketones, carboxylic acids, esters, nitriles, and amides from alcohols in excellent yields in the presence of air.

Nitrogen Atom Transfer Catalysis by Metallonitrene C?H Insertion: Photocatalytic Amidation of Aldehydes

C?H amination and amidation by catalytic nitrene transfer are well-established and typically proceed via electrophilic attack of nitrenoid intermediates. In contrast, the insertion of (formal) terminal nitride ligands into C?H bonds is much less developed and catalytic nitrogen atom transfer remains unknown. We here report the synthesis of a formal terminal nitride complex of palladium. Photocrystallographic, magnetic, and computational characterization support the assignment as an authentic metallonitrene (Pd?N) with a diradical nitrogen ligand that is singly bonded to PdII. Despite the subvalent nitrene character, selective C?H insertion with aldehydes follows nucleophilic selectivity. Transamidation of the benzamide product is enabled by reaction with N3SiMe3. Based on these results, a photocatalytic protocol for aldehyde C?H trimethylsilylamidation was developed that exhibits inverted, nucleophilic selectivity as compared to typical nitrene transfer catalysis. This first example of catalytic C?H nitrogen atom transfer offers facile access to primary amides after deprotection.

Visible light-mediated synthesis of amides from carboxylic acids and amine-boranes

Here, a photocatalytic deoxygenative amidation protocol using readily available amine-boranes and carboxylic acids is described. This approach features mild conditions, moderate-to-good yields, easy scale-up, and up to 62 examples of functionalized amides with diverse substituents. The synthetic robustness of this method was also demonstrated by its application in the late-stage functionalization of several pharmaceutical molecules.

Application of acylthiourea compound in preparation of medicines for resisting enterovirus

The invention discloses an application of an acylthiourea compound in preparation of an anti-enterovirus drug, and belongs to the technical field of medicines. The structure of the acylthiourea compound of the present invention is as shown in the general

Ring Opening/Site Selective Cleavage in N-Acyl Glutarimide to Synthesize Primary Amides

A LiOH-promoted hydrolysis selective C-N cleavage of twisted N-acyl glutarimide for the synthesis of primary amides under mild conditions has been developed. The reaction is triggered by a ring opening of glutarimide followed by C-N cleavage to afford primary amides using 2 equiv of LiOH as the base at room temperature. The efficacy of the reactions was considered and administrated for various aryl and alkyl substituents in good yield with high selectivity. Moreover, gram-scale synthesis of primary amides using a continuous flow method was achieved. It is noted that our new methodology can apply under both batch and flow conditions for synthetic and industrial applications.

Unlocking Amides through Selective C–N Bond Cleavage: Allyl Bromide-Mediated Divergent Synthesis of Nitrogen-Containing Functional Groups

We report a new set of reactions based on the unlocking of amides through simple treatment with allyl bromide, creating a common platform for accessing a diverse range of nitrogen-containing functional groups such as primary amides, sulfonamides, primary amines, N-acyl compounds (esters, thioesters, amides), and N-sulfonyl esters. The method has potential industrial applicability, as demonstrated through gram-scale syntheses in batch and in a continuous flow system.

Efficient nitriding reagent and application thereof

The invention discloses an efficient nitriding reagent and application thereof, wherein the nitriding reagent comprises nitrogen oxide, an active agent, a reducing agent and an organic solvent. By applying the nitriding reagent, nitrogen-containing compounds such as amide, nitrile and the like can be produced, and the method is simple in condition, low in waste discharge amount and simple in reaction equipment.

Aerobic oxidation of primary amines to amides catalyzed by an annulated mesoionic carbene (MIC) stabilized Ru complex

Catalytic aerobic oxidation of primary amines to the amides, using the precatalyst [Ru(COD)(L1)Br2] (1) bearing an annulated π-conjugated imidazo[1,2-a][1,8]naphthyridine-based mesoionic carbene ligand L1, is disclosed. This catalytic protocol is distinguished by its high activity and selectivity, wide substrate scope and modest reaction conditions. A variety of primary amines, RCH2NH2 (R = aliphatic, aromatic and heteroaromatic), are converted to the corresponding amides using ambient air as an oxidant in the presence of a sub-stoichiometric amount of KOtBu in tBuOH. A set of control experiments, Hammett relationships, kinetic studies and DFT calculations are undertaken to divulge mechanistic details of the amine oxidation using 1. The catalytic reaction involves abstraction of two amine protons and two benzylic hydrogen atoms of the metal-bound primary amine by the oxo and hydroxo ligands, respectively. A β-hydride transfer step for the benzylic C-H bond cleavage is not supported by Hammett studies. The nitrile generated by the catalytic oxidation undergoes hydration to afford the amide as the final product. This journal is

Synthesis of CF3-containing isoindolinone derivatives through rhodium-catalyzed oxidative coupling of benzamides with 2-trifluoromethylacrylate

The oxidative coupling of benzamides with methyl 2- trifluoromethylacrylate proceeds smoothly under rhodium(III) catalysis to produce trifluoromethyl-substituted isoindolinone derivatives. The catalyst system [CpERhCl2]2/AgSbF6 is effective for the oxidat

Supported palladium catalyzed aminocarbonylation of aryl iodides employing bench-stable CO and NH3surrogates

A simple, efficient and phosphine free protocol for carbonylative synthesis of primary aromatic amides under polystyrene supported palladium (Pd?PS) nanoparticle (NP) catalyzed conditions has been demonstrated. Herein, instead of using two toxic and difficult to handle gases simultaneously, we have employed the solid, economical, bench stable oxalic acid as the CO source and ammonium carbamate as the NH3source in a single pot reaction. For the first time, we have applied two non-gaseous surrogates simultaneously under heterogeneous catalyst (Pd?PS) conditions for the synthesis of primary amides using an easy to handle double-vial (DV) system. The developed strategy showed a good functional group tolerance towards a wide range of aryl iodides and afforded primary aromatic amides in good yields. The Pd?PS catalyst was easy to separate and can be recycled up to four consecutive runs with small loss in catalytic activity. We have successfully extended the scope of the methodology to the synthesis of isoindole-1,3-diones from 1,2-dihalobenzene, 2-halobenzoates and 2-halobenzoic acid following double and single carbonylative cyclization approaches.